1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

Base Information

Chemical Name:1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea
CAS No.:1350897-02-7
Molecular Formula:C₁₈H₁₅F₆N₅S
Molecular Weight:447.407
Hs Code.:

Synonyms:1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

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Chemical Property of 1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

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Technology Process of 1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

There total 3 articles about 1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 130406-34-7
(S)-1-azido-3-phenylpropan-2-amine

: 1350897-02-7
1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.09.006

Reference yield:

: 141403-49-8,72196-67-9
(2S)-2-[N-(tert-butoxycarbonyl)amino]-3-phenyl-O-(4-methylphenylsulfonyl)propan-1-ol

: 1350897-02-7
1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 7 h / 45 °C

2: hydrogenchloride / diethyl ether / 24 h / 20 °C / Inert atmosphere; Cooling with ice

3: tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; sodium azide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja409121s

Reference yield:

: 134557-74-7
tert-butyl [(2S)-1-azido-3-phenylpropan-2-yl]carbamate

: 1350897-02-7
1-[(2S)-1-azido-3-phenylpropan-2-yl]-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether / 24 h / 20 °C / Inert atmosphere; Cooling with ice

2: tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja409121s