N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

Base Information

Chemical Name:N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide
CAS No.:1449305-52-5
Molecular Formula:C₂₁H₁₉N₃O₃
Molecular Weight:361.4
Hs Code.:

Synonyms:N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

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Chemical Property of N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

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Technology Process of N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

There total 4 articles about N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1449305-47-8
5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

: 1449305-52-5
N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

Guidance literature:: 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

With hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1449305-45-6
ethyl 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

: 1449305-52-5
N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

With chloroformic acid ethyl ester; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 1082051-77-1
7-iodo-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

: 1449305-52-5
N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 2 h / 55 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloroformic acid ethyl ester; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2013.05.017