5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

Base Information

• Chemical Name: 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid
• CAS No.: 1449305-47-8
• Molecular Formula: C₂₁H₁₈N₂O₃
• Molecular Weight: 346.386

Synonyms:5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

Chemical Property of 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

There total 3 articles about 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid (1449305-45-6) → 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid (1449305-47-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

7-iodo-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one (1082051-77-1) → 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid (1449305-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 2 h / 55 °C / Inert atmosphere

2: sodium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

ethyl 4-pentynoate (63093-41-4) → 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid (1449305-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 2 h / 55 °C / Inert atmosphere

2: sodium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.ejmech.2013.05.017

upstream raw materials:

ethyl 5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynoic acid

7-iodo-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one

ethyl 4-pentynoate

Downstream raw materials:

N-hydroxy-5-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-7-yl)pent-4-ynamide

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