8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane
CAS No.:1204302-78-2
Molecular Formula:C₂₄H₂₆F₃NO₃
Molecular Weight:433.471
Hs Code.:

Synonyms:8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane

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Technology Process of 8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane

There total 1 articles about 8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

: 1204302-62-4
8-ethoxycarbonyl-3β-(4-trifluoromethylphenyl)-3α-hydroxy-8-azabicyclo[3.2.1]octane

: 100-39-0
benzyl bromide

: 1204302-78-2
8-ethoxycarbonyl-3α-phenylmethoxy-3β-(4-trifluorophenyl)-8-azabicyclo[3.2.1]octane

Guidance literature:: 8-ethoxycarbonyl-3β-(4-trifluoromethylphenyl)-3α-hydroxy-8-azabicyclo[3.2.1]octane; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.10.087