N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

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Chemical Name:N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine
CAS No.:865788-41-6
Molecular Formula:C₂₀H₂₃BrN₄
Molecular Weight:399.333
Hs Code.:

Synonyms:N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

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Chemical Property of N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

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Technology Process of N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

There total 8 articles about N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 865788-38-1
(2-{N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]amino}ethyl)carbamic acid tert-butyl ester

: 865788-41-6
N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

Guidance literature:: (2-{N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]amino}ethyl)carbamic acid tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

In N,N-dimethyl-formamide; for 0.166667h;

Reference yield:

: 443998-69-4
{2-[(4-bromophenyl)amino]ethyl}carbamic acid tert-butyl ester

: 865788-41-6
N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

1.2: 98 percent Turnov_. / sodium hydride; imidazole / tetrahydrofuran / 1 h / -78 °C

2.1: sodium hydride / dimethylformamide / 0.08 h / 0 °C

2.2: dimethylformamide / 0.17 h

3.1: TFA / 0.17 h

With sodium hydride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060081v

Reference yield:

: 106-40-1
4-bromo-aniline

: 865788-41-6
N'-benzyl-N-(4-bromophenyl)-N-[(3-methyl-3H-imidazol-4-yl)methyl]ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol / 0.33 h

2.1: 3.1 g / sodium cyanoborohydride / methanol / 1 h

3.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

3.2: 98 percent Turnov_. / sodium hydride; imidazole / tetrahydrofuran / 1 h / -78 °C

4.1: sodium hydride / dimethylformamide / 0.08 h / 0 °C

4.2: dimethylformamide / 0.17 h

5.1: TFA / 0.17 h

With sodium hydride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm060081v