methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

Base Information

Chemical Name:methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate
CAS No.:1431956-33-0
Molecular Formula:C₃₈H₃₆NO₆P
Molecular Weight:633.681
Hs Code.:

Synonyms:methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

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Chemical Property of methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

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Technology Process of methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

There total 5 articles about methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431956-32-9
C₁₈H₂₂O₇

: 16640-68-9
cyanomethylene triphenylphosphorane

: 1431956-33-0
methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ol400864f

Reference yield:

: 1431956-27-2
C₁₈H₂₆O₈

: 1431956-33-0
methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium chlorochromate; sodium acetate / dichloromethane / 3 h / 20 °C

2: potassium carbonate / methanol / 20 °C

3: potassium hydroxide / methanol; water / 8 h / 0 - 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; sodium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; potassium hydroxide; In methanol; dichloromethane; water; 2: |Seyferth-Gilbert Homologation;
DOI:10.1021/ol400864f

Reference yield:

: 1402733-49-6
methyl 4-allyl-3-(ethoxymethoxy)-2-methoxy-6-(2-methoxy-2-oxoethyl)benzoate

: 1431956-33-0
methyl 4-(but-3-yn-1-yl)-6-(3-cyano-2-oxo-3-(triphenylphosphoranylidene)propyl)-3-(ethoxymethoxy)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 - 20 °C

2: pyridinium chlorochromate; sodium acetate / dichloromethane / 3 h / 20 °C

3: potassium carbonate / methanol / 20 °C

4: potassium hydroxide / methanol; water / 8 h / 0 - 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; sodium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 3: |Seyferth-Gilbert Homologation;
DOI:10.1021/ol400864f