2-Methyl-5-phenyl-1,3-oxazole-4-carboxylic acid

Base Information

Chemical Name:2-Methyl-5-phenyl-1,3-oxazole-4-carboxylic acid
CAS No.:91137-53-0
Molecular Formula:C₁₁H₉NO₃
Molecular Weight:203.197
Hs Code.:
European Community (EC) Number:850-376-2

Synonyms:2-methyl-5-phenyl-1,3-oxazole-4-carboxylic acid;91137-53-0;2-methyl-5-phenyloxazole-4-carboxylic acid;SCHEMBL1167223;GEAPKHXZFUKEDK-UHFFFAOYSA-N;AKOS023093675;2-methyl-5-phenyloxazole-4-carboxylicacid;2-methyl-5-phenyl-oxazole-4-carboxylic acid;5-phenyl-2-methyl-oxazole-4-carboxylic acid;EN300-135569;G60076;Z1508919992

Suppliers and Price of 2-Methyl-5-phenyl-1,3-oxazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-methyl-5-phenyl-1,3-oxazole-4-carboxylicAcid
100mg
$ 240.00

Labseeker
2-Methyl-5-phenyl-1,3-oxazole-4-carboxylicacid 95
5g
$ 1666.00

AK Scientific
2-Methyl-5-phenyl-1,3-oxazole-4-carboxylicacid
1g
$ 734.00

Total 3 raw suppliers

Chemical Property of 2-Methyl-5-phenyl-1,3-oxazole-4-carboxylic acid

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:203.058243149
Heavy Atom Count:15
Complexity:238

Purity/Quality:: 2-methyl-5-phenyl-1,3-oxazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC(=C(O1)C2=CC=CC=C2)C(=O)O

Technology Process of 2-Methyl-5-phenyl-1,3-oxazole-4-carboxylic acid

There total 6 articles about 2-Methyl-5-phenyl-1,3-oxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1198279-56-9
benzyl 2-methyl-5-phenyloxazole-4-carboxylate

: 91137-53-0
2-methyl-5-phenyl-4-oxazolecarboxylic acid

Guidance literature:: With 25% Pd/C; hydrogen; In ethyl acetate; at 20 ℃; under 760.051 Torr;
DOI:10.1021/jo9016265

Reference yield: 67.0%

: 92029-40-8
ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate

: 91137-53-0
2-methyl-5-phenyl-4-oxazolecarboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 25 ℃; for 2h;
DOI:10.1021/jo00300a013

Reference yield:

: 127916-11-4
ethyl bezoylacetate oxime

: 91137-53-0
2-methyl-5-phenyl-4-oxazolecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate, HgCl₂, Zn / 40 h / Heating

2: thionyl chloride / CHCl₃ / 1. 0 deg C, 30 min 2. 25 deg C, overnight 3. reflux, 1 h 45 min 4. 25 deg C, overnight

3: 67 percent / 2 N NaOH / ethanol; H₂O / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; sodium acetate; mercury dichloride; zinc; In ethanol; chloroform; water;
DOI:10.1021/jo00300a013