ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate

Base Information

• Chemical Name: ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate
• CAS No.: 92029-40-8
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.251
• Mol file: 92029-40-8.mol

Synonyms:ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate

Chemical Property of ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate

There total 6 articles about ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenylpropynoic acid ethyl ester (2216-94-6) + acetonitrile (75-05-8,26809-02-9) → ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate (92029-40-8) + 3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester (134390-45-7)

Guidance literature:

With 2-chloropyridine-N-oxide; chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; In neat (no solvent); at 80 ℃; for 6h; Reagent/catalyst; Temperature;

DOI:10.1002/adsc.201900097

Reference yield: 81.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + acetonitrile (75-05-8,26809-02-9) → ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate (92029-40-8)

Guidance literature:

With iodosylbenzene; bis(trifluoromethanesulfonyl)amide; at 0 - 80 ℃; for 3.08333h; Inert atmosphere;

DOI:10.3390/molecules170911046

Reference yield:

ethyl (2-acetamidobezoyl)acetate → ethyl 2-methyl-5-phenyl-4-oxazolecarboxylate (92029-40-8)

Guidance literature:

With thionyl chloride; In chloroform; Yield given; 1. 0 deg C, 30 min 2. 25 deg C, overnight 3. reflux, 1 h 45 min 4. 25 deg C, overnight;

DOI:10.1021/jo00300a013

upstream raw materials:

α-acetylamino-β-bromo-cinnamic acid ethyl ester

ethyl bezoylacetate oxime

ethyl 3-oxo-3-phenylpropionate

acetonitrile

Downstream raw materials:

2-methyl-5-phenyl-4-oxazolecarboxylic acid

1-(2-methyl-5-phenyloxazol-4-yl)ethan-1-one

2-methyl-5-phenyl-oxazole-4-carbonyl chloride