1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

Base Information

Chemical Name:1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione
CAS No.:1062614-38-3
Molecular Formula:C₁₇H₁₁BrF₄O₃
Molecular Weight:419.17
Hs Code.:

Synonyms:1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

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Chemical Property of 1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

Chemical Property:

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Technology Process of 1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

There total 7 articles about 1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.3%

: 1062614-35-0
2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

: 1062614-38-3
1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

Guidance literature:: With dimethyl sulfoxide; dichloro bis(acetonitrile) palladium(II); at 140 ℃; for 4h;

Reference yield:

: 198277-06-4
2-(5-bromo-2-hydroxyphenyl)-1-ethanol

: 1062614-38-3
1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / water; N,N-dimethyl-formamide / 120 °C

2: diethylamino-sulfur trifluoride / dichloromethane / -40 °C

3: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 60 °C

4: methanol; potassium carbonate / 3 h / 25 °C

5: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h

6: dimethyl sulfoxide / dichloro bis(acetonitrile) palladium(II) / 4 h / 140 °C

With methanol; copper(l) iodide; diethylamino-sulfur trifluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro bis(acetonitrile) palladium(II); In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1062614-00-9
2-(5-bromo-2-(difluoromethoxy)phenyl)ethanol

: 1062614-38-3
1-(3-bromo-4-fluorophenyl)-2-(4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 5 steps

1: diethylamino-sulfur trifluoride / dichloromethane / -40 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 60 °C

3: methanol; potassium carbonate / 3 h / 25 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h

5: dimethyl sulfoxide / dichloro bis(acetonitrile) palladium(II) / 4 h / 140 °C

With methanol; copper(l) iodide; diethylamino-sulfur trifluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; dichloro bis(acetonitrile) palladium(II); In dichloromethane; N,N-dimethyl-formamide;