2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

Base Information

Chemical Name:2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene
CAS No.:1062614-35-0
Molecular Formula:C₁₇H₁₁BrF₄O
Molecular Weight:387.171
Hs Code.:

Synonyms:2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

Chemical Property:

Purity/Quality:

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Technology Process of 2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

There total 6 articles about 2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 811842-30-5
2-bromo-1-fluoro-4-iodobenzene

: 1062614-31-6
1-(difluoromethoxy)-4-ethynyl-2-(2-fluoroethyl)benzene

: 1062614-35-0
2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 198277-06-4
2-(5-bromo-2-hydroxyphenyl)-1-ethanol

: 1062614-35-0
2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / water; N,N-dimethyl-formamide / 120 °C

2: diethylamino-sulfur trifluoride / dichloromethane / -40 °C

3: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 60 °C

4: methanol; potassium carbonate / 3 h / 25 °C

5: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h

With methanol; copper(l) iodide; diethylamino-sulfur trifluoride; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1062614-00-9
2-(5-bromo-2-(difluoromethoxy)phenyl)ethanol

: 1062614-35-0
2-bromo-4-((4-(difluoromethoxy)-3-(2-fluoroethyl)phenyl)ethynyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 4 steps

1: diethylamino-sulfur trifluoride / dichloromethane / -40 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 60 °C

3: methanol; potassium carbonate / 3 h / 25 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h

With methanol; copper(l) iodide; diethylamino-sulfur trifluoride; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;