5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

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Chemical Name:5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester
CAS No.:1351343-58-2
Molecular Formula:C₃₁H₃₈F₃N₇O₆
Molecular Weight:661.681
Hs Code.:

5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

Synonyms:5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

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Chemical Property of 5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

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Technology Process of 5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

There total 12 articles about 5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351343-57-1
5-trichloromethyl-[1,2,4]oxadiazol-3-carboxylic acid ethyl ester

: 1351343-21-9
[(3R,4S)-1-[5-((S)-1-piperidin-4-yl-ethoxy)pyrimidin-2-yl]-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351343-58-2
5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1351343-58-2
5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: dimethylsulfide borane complex; Trimethyl borate; (S)-diphenylprolinol / tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / platinum oxide / methanol / 18 h / 38002.6 Torr / Inert atmosphere

3.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.2: 4 h / 0 - 20 °C

5.1: cesium fluoride / ISOPROPYLAMIDE / 168 h / 60 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 109 h / 90 - 140 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 - 50 °C

8.1: N,N-dimethyl-formamide / 2 h / 50 °C

With Trimethyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 27854-88-2,42732-22-9
(R)-1-(4-pyridinyl)ethanol

: 1351343-58-2
5-[4-((S)-1-{2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,4,5-trifluoro-phenyl)pyrrolidin-1-yl]pyrimidin-5-yloxy}ethyl)piperidin-1-yl]-[1,2,4]oxadiazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / platinum oxide / methanol / 18 h / 38002.6 Torr / Inert atmosphere

2.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.2: 4 h / 0 - 20 °C

4.1: cesium fluoride / ISOPROPYLAMIDE / 168 h / 60 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 109 h / 90 - 140 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 - 50 °C

7.1: N,N-dimethyl-formamide / 2 h / 50 °C

With hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; dimethyl sulfoxide; N,N-dimethyl-formamide;