diethyl N-<4-<methyl>benzoyl>-L-glutamate

Base Information

• Chemical Name: diethyl N-<4-<methyl>benzoyl>-L-glutamate
• CAS No.: 133446-62-5
• Molecular Formula: C₂₇H₃₂N₄O₆
• Molecular Weight: 508.574
• Mol file: 133446-62-5.mol

Synonyms:diethyl N-<4-<methyl>benzoyl>-L-glutamate

Chemical Property of diethyl N-<4-<methyl>benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl N-<4-<methyl>benzoyl>-L-glutamate

There total 6 articles about diethyl N-<4-<methyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

diethyl N-<4-<methyl>benzoyl>-L-glutamate (133446-61-4) + methyl iodide (74-88-4) → diethyl N-<4-<methyl>benzoyl>-L-glutamate (133446-62-5)

Guidance literature:

With calcium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 2h;

DOI:10.1021/jm00111a042

Reference yield:

2-methyl-6-nitroquinazolin-4(3H)-one (24688-36-6) → diethyl N-<4-<methyl>benzoyl>-L-glutamate (133446-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10percent Pd/C / methanol / 6.5 h

2: 48 percent / CaCO₃ / dimethylformamide / 4.5 h / 86 °C

3: 11 percent / CaCO₃ / dimethylformamide / 2 h / 65 °C

With hydrogen; calcium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00111a042

Reference yield:

6-amino-3,4-dihydro-2-methyl-4-oxoquinazoline (17329-24-7) → diethyl N-<4-<methyl>benzoyl>-L-glutamate (133446-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / CaCO₃ / dimethylformamide / 4.5 h / 86 °C

2: 11 percent / CaCO₃ / dimethylformamide / 2 h / 65 °C

With calcium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00111a042

upstream raw materials:

diethyl N-<4-<methyl>benzoyl>-L-glutamate

methyl iodide

6-amino-3,4-dihydro-2-methyl-4-oxoquinazoline

p-(chloromethyl)benzoyl chloride

Downstream raw materials:

2-desamino-2,9-dimethyl-5,8-dideazaisofolic acid