tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

Base Information

Chemical Name:tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate
CAS No.:1352083-19-2
Molecular Formula:C₁₈H₂₅N₃O₆S
Molecular Weight:411.479
Hs Code.:

Synonyms:tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

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Chemical Property of tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

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Technology Process of tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

There total 4 articles about tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3144-09-0
methanesulfonamide

: 1352083-18-1
4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoic acid

: 1352083-19-2
tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

Guidance literature:: 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

methanesulfonamide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 120728-10-1
1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid

: 1352083-19-2
tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / isopropyl alcohol; 1,4-dioxane / 0.75 h / 60 °C

2.2: 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 1352083-19-2
tert-butyl [1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / isopropyl alcohol; 1,4-dioxane / 0.75 h / 60 °C

2.2: 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;