3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

Base Information

Chemical Name:3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide
CAS No.:1352082-81-5
Molecular Formula:C₃₃H₃₅N₅O₅S
Molecular Weight:613.737
Hs Code.:

Synonyms:3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

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Chemical Property of 3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

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Technology Process of 3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

There total 13 articles about 3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1352082-73-5
3-cyclohexyl-2-phenyl-2H-indazole-6-carboxylic acid

: 1352083-20-5
4-{[(1-aminocyclobutyl)carbonyl]amino}-N-(methylsulfonyl)benzamide hydrochloride

: 1352082-81-5
3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 852620-79-2
2-azido-4-bromobenzoic acid

: 1352082-81-5
3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: trichlorophosphate / 2 h / 95 °C

2.2: 5 °C / Cooling with ice

3.1: 1.5 h / 175 °C

4.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

5.1: sodium hydroxide; water / ethanol / 4 h / Reflux

5.2: pH 2

6.1: ammonium formate / palladium 10% on activated carbon / methanol / Inert atmosphere; Reflux

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With water; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1352082-81-5
3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / water / 0.5 h / 5 - 80 °C

1.2: 1 h / 0 °C

1.3: 3 h / 20 °C

2.1: HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 4 h / 0 - 20 °C

3.1: trichlorophosphate / 2 h / 95 °C

3.2: 5 °C / Cooling with ice

4.1: 1.5 h / 175 °C

5.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,4-dioxane; water / 1 h / Reflux; Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 4 h / Reflux

6.2: pH 2

7.1: ammonium formate / palladium 10% on activated carbon / methanol / Inert atmosphere; Reflux

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; ammonium formate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;