(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

Base Information

Chemical Name:(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine
CAS No.:137664-50-7
Molecular Formula:C₂₄H₃₂N₂O₂Si
Molecular Weight:408.616
Hs Code.:

Synonyms:(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

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Chemical Property of (R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

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Technology Process of (R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

There total 9 articles about (R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 137664-57-4
2-((R)-3-Azido-1-methyl-propyl)-4-(tert-butyl-diphenyl-silanyloxymethyl)-oxazole

: 137664-50-7
(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1016/S0040-4039(00)93480-4

Reference yield:

: 137664-52-9
(R)-4-Azido-2-methyl-butyric acid

: 137664-50-7
(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / diethyl phosphoryl cyanide, Et₃N / dimethylformamide / 0 - 25 °C

2: pyridine / CH₂Cl₂

3: pyridine hydrochloride / dimethylformamide / 40 h / 25 °C

4: AgOTf / benzene / 0.67 h / Heating

5: 50 percent / nickel peroxide hydrate / benzene / 40 h / 78 °C

6: 75 percent / DIBAL / tetrahydrofuran / 0 °C

7: 70 percent / imidazole, DMAP / dimethylformamide

8: 90 percent / H₂ / 5percent Pd-C / ethanol / Ambient temperature

With pyridine; 1H-imidazole; dmap; nickel(IV) oxide; diethyl cyanophosphonate; hydrogen; silver trifluoromethanesulfonate; pyridine hydrochloride; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)93480-4

Reference yield:

: 137664-56-3
[2-((R)-3-Azido-1-methyl-propyl)-oxazol-4-yl]-methanol

: 137664-50-7
(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / imidazole, DMAP / dimethylformamide

2: 90 percent / H₂ / 5percent Pd-C / ethanol / Ambient temperature

With 1H-imidazole; dmap; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)93480-4