[(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester
CAS No.:137664-64-3
Molecular Formula:C₃₈H₅₅N₃O₈Si
Molecular Weight:709.955
Hs Code.:

[(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

There total 21 articles about [(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137664-52-9
(R)-4-Azido-2-methyl-butyric acid

: 137664-64-3
[(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 77 percent / diethyl phosphoryl cyanide, Et₃N / dimethylformamide / 0 - 25 °C

2: pyridine / CH₂Cl₂

3: pyridine hydrochloride / dimethylformamide / 40 h / 25 °C

4: AgOTf / benzene / 0.67 h / Heating

5: 50 percent / nickel peroxide hydrate / benzene / 40 h / 78 °C

6: 75 percent / DIBAL / tetrahydrofuran / 0 °C

7: 70 percent / imidazole, DMAP / dimethylformamide

8: 90 percent / H₂ / 5percent Pd-C / ethanol / Ambient temperature

9: 1) AlMe₃ / 1) CH₂Cl₂, 0 deg C to 25 deg C, 30 min, 2) CH₂Cl₂, reflux, 9 h

With pyridine; 1H-imidazole; dmap; nickel(IV) oxide; diethyl cyanophosphonate; hydrogen; trimethylaluminum; silver trifluoromethanesulfonate; pyridine hydrochloride; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)93480-4

Reference yield:

: 137664-56-3
[2-((R)-3-Azido-1-methyl-propyl)-oxazol-4-yl]-methanol

: 137664-64-3
[(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / imidazole, DMAP / dimethylformamide

2: 90 percent / H₂ / 5percent Pd-C / ethanol / Ambient temperature

3: 1) AlMe₃ / 1) CH₂Cl₂, 0 deg C to 25 deg C, 30 min, 2) CH₂Cl₂, reflux, 9 h

With 1H-imidazole; dmap; hydrogen; trimethylaluminum; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)93480-4

Reference yield:

: 137664-53-0
(S)-2-((R)-4-Azido-2-methyl-butyrylamino)-3-hydroxy-propionic acid methyl ester

: 137664-64-3
[(R)-1-((4R,5R)-5-{(R)-3-[4-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-2-yl]-butylcarbamoyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxy-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / CH₂Cl₂

2: pyridine hydrochloride / dimethylformamide / 40 h / 25 °C

3: AgOTf / benzene / 0.67 h / Heating

4: 50 percent / nickel peroxide hydrate / benzene / 40 h / 78 °C

5: 75 percent / DIBAL / tetrahydrofuran / 0 °C

6: 70 percent / imidazole, DMAP / dimethylformamide

7: 90 percent / H₂ / 5percent Pd-C / ethanol / Ambient temperature

8: 1) AlMe₃ / 1) CH₂Cl₂, 0 deg C to 25 deg C, 30 min, 2) CH₂Cl₂, reflux, 9 h

With pyridine; 1H-imidazole; dmap; nickel(IV) oxide; hydrogen; trimethylaluminum; silver trifluoromethanesulfonate; pyridine hydrochloride; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)93480-4