{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Base Information

Chemical Name:{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid
CAS No.:1322081-31-1
Molecular Formula:C₂₂H₂₀F₃N₃O₃
Molecular Weight:431.414
Hs Code.:

Synonyms:{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

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Chemical Property of {3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Chemical Property:

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Technology Process of {3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

There total 7 articles about {3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₂F₃N₃O₃

: 1322081-31-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: With water; sodium hydroxide;

Reference yield:

: 32701-82-9
(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid

: 1322081-31-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 18 h / 20 °C

2: nitric acid / sulfuric acid / 0.33 h / -7 - 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

5: sodium hydroxide; water

With water; hydrogen; nitric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1283378-96-0
(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester

: 1322081-31-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid / sulfuric acid / 0.33 h / -7 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

4: sodium hydroxide; water

With water; hydrogen; nitric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;