Technology Process of N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide
There total 8 articles about N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
dmap;
In
dichloromethane;
at 30 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / acetonitrile / 1 h / 20 °C
2: hydrogen / palladium 10% on activated carbon / methanol
3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C
4: sodium hydroxide; water
5: dicyclohexyl-carbodiimide / dmap / dichloromethane / 3 h / 30 °C
With
water; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide;
dmap; palladium 10% on activated carbon;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride / 18 h / 20 °C
2: nitric acid / sulfuric acid / 0.33 h / -7 - 20 °C
3: hydrogen / palladium 10% on activated carbon / methanol
4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C
5: sodium hydroxide; water
6: dicyclohexyl-carbodiimide / dmap / dichloromethane / 3 h / 30 °C
With
water; hydrogen; nitric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide;
hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon;
In
methanol; dichloromethane; N,N-dimethyl-formamide;