N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide
CAS No.:1322084-19-4
Molecular Formula:C₂₆H₂₉F₃N₄O₄S
Molecular Weight:550.602
Hs Code.:

Synonyms:N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

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Chemical Property of N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

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Technology Process of N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

There total 8 articles about N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1322081-31-1
{3,5-dimethyl-1-[4-(4-trifluoromethyl-benzoylamino)-benzyl]-1H-pyrazol-4-yl}-acetic acid

: 34813-49-5
t-butylsulfonamide

: 1322084-19-4
N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

Guidance literature:: With dicyclohexyl-carbodiimide; dmap; In dichloromethane; at 30 ℃; for 3h;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1322084-19-4
N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

4: sodium hydroxide; water

5: dicyclohexyl-carbodiimide / dmap / dichloromethane / 3 h / 30 °C

With water; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; dmap; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 32701-82-9
(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid

: 1322084-19-4
N-{4-[(3,5-dimethyl-4-{[(2-methylpropane-2-sulfonyl)carbamoyl]methyl}-1H-pyrazol-1-yl)methyl]phenyl}-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 18 h / 20 °C

2: nitric acid / sulfuric acid / 0.33 h / -7 - 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 18 h / 20 °C

5: sodium hydroxide; water

6: dicyclohexyl-carbodiimide / dmap / dichloromethane / 3 h / 30 °C

With water; hydrogen; nitric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;