((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

Base Information

Chemical Name:((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate
CAS No.:1584714-50-0
Molecular Formula:C₂₇H₂₉F₄N₄O₇P
Molecular Weight:628.517
Hs Code.:

((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

Synonyms:((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

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Chemical Property of ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

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Technology Process of ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

There total 3 articles about ((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1584715-93-4
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

: 1584714-50-0
((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1.75h;

Reference yield:

: (2R,3S)-3-(cyclopropylmethyl)-N₁-((S)-9-fluoro-1-(methylthiomethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

: 1584714-50-0
((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

1.2: 21 h / 20 - 65 °C / Inert atmosphere

1.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

2.1: trifluoroacetic acid / dichloromethane / 1.75 h / 0 °C

With sulfuryl dichloride; triethylamine hydrochloride; trifluoroacetic acid; In dichloromethane;

Reference yield:

: C₂₆H₂₆F₄N₄O₃

: 1584714-50-0
((3S)-3-(((2R)-2-((1S)-2-amino-1-(cyclopropylmethyl)-2-oxoethyl)-5,5,5-trifluoropentanoyl)amino)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.92 h / 20 °C / Inert atmosphere

2.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

2.2: 21 h / 20 - 65 °C / Inert atmosphere

2.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

3.1: trifluoroacetic acid / dichloromethane / 1.75 h / 0 °C

With sulfuryl dichloride; triethylamine hydrochloride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;