((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

Base Information

Chemical Name:((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate
CAS No.:1584715-93-4
Molecular Formula:C₃₅H₄₅F₄N₄O₇P
Molecular Weight:740.732
Hs Code.:

((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

Synonyms:((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

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Chemical Property of ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

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Technology Process of ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

There total 2 articles about ((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.7%

: (2R,3S)-3-(cyclopropylmethyl)-N₁-((S)-9-fluoro-1-(methylthiomethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

: 68695-48-7
di-tert-butyl phosphoric acid tetra-n-butylammonium salt

: 1584715-93-4
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

Guidance literature:: (2R,3S)-3-(cyclopropylmethyl)-N₁-((S)-9-fluoro-1-(methylthiomethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide; With sulfuryl dichloride; triethylamine hydrochloride; In dichloromethane; at 20 ℃; for 0.833333h; Inert atmosphere;

di-tert-butyl phosphoric acid tetra-n-butylammonium salt; With sodium iodide; In tetrahydrofuran; at 20 - 65 ℃; for 21h; Inert atmosphere;

In methanol; carbon dioxide; Supercritical conditions; liquid CO₂;

Reference yield:

: C₂₆H₂₆F₄N₄O₃

: 1584715-93-4
((S)-3-((R)-2-((S)-1-amino-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanamido)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.92 h / 20 °C / Inert atmosphere

2.1: triethylamine hydrochloride; sulfuryl dichloride / dichloromethane / 0.83 h / 20 °C / Inert atmosphere

2.2: 21 h / 20 - 65 °C / Inert atmosphere

2.3: Berger SFC MGII / Supercritical conditions; liquid CO₂

With sulfuryl dichloride; triethylamine hydrochloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;