5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide
CAS No.:1221166-81-9
Molecular Formula:C₂₃H₂₄ClFN₂O₄S
Molecular Weight:478.972
Hs Code.:

Synonyms:5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

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Chemical Property of 5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

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Technology Process of 5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

There total 6 articles about 5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₄ClFN₂O₇S₂

: 1221166-81-9
5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 60 ℃; for 1.33333h;

Reference yield:

2-chloro-4-fluorophenylboronic acid: 313545-72-1
2-chloro-4-fluorophenylboronic acid

: 1221166-81-9
5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 9 h / 110 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 4 h / 80 °C

3.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 20 °C

5.1: sodium t-butanolate / N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

5.2: 2 h / 70 °C / Inert atmosphere

5.3: 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 1.33 h / 60 °C

With hydrogenchloride; oxalyl dichloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 881674-29-9
methyl 5-bromo-4-methyl-1H-pyrrole-3-carboxylate

: 1221166-81-9
5-(2-chloro-4-fluorophenyl)-1-[(1R,2S)-2-hydroxy-1-methylpropyl]-4-methyl-N-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 9 h / 110 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 4 h / 80 °C

3.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 20 °C

5.1: sodium t-butanolate / N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

5.2: 2 h / 70 °C / Inert atmosphere

5.3: 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 1.33 h / 60 °C

With hydrogenchloride; oxalyl dichloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; 1.1: Suzuki Coupling;