N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester

Base Information

• Chemical Name: N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester
• CAS No.: 103777-98-6
• Molecular Formula: C₂₉H₄₄N₂O₉
• Molecular Weight: 564.676
• Mol file: 103777-98-6.mol

Synonyms:N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester

Chemical Property of N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester

There total 4 articles about N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-aspartic acid di-tert-butyl ester (13795-73-8) + (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester (5891-45-2) → N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester (103777-98-6)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) THF, -20 deg C, 10 min, 2.) THF, a) -20 deg C, 10 min, b) from -20 deg to RT;

DOI:10.1021/jm00046a014

Reference yield:

acetic acid tert-butyl ester (540-88-5) → N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester (103777-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) HClO₄, (ii) aq. NaOH, acetone

2: (i) 1-ethyl-piperidine, ClCO₂Et, toluene, (ii) /BRN= 5652807/

Reference yield:

(S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester (4652-65-7) → N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester (103777-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) HClO₄, (ii) aq. NaOH, acetone

2: (i) 1-ethyl-piperidine, ClCO₂Et, toluene, (ii) /BRN= 5652807/

upstream raw materials:

(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

L-aspartic acid di-tert-butyl ester hydrochloride

L-aspartic acid di-tert-butyl ester

acetic acid tert-butyl ester

Downstream raw materials:

(S)-2-((S)-4-tert-Butoxycarbonyl-4-{4-[(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-butyrylamino)-succinic acid di-tert-butyl ester