3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester

Base Information

• Chemical Name: 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester
• CAS No.: 1357899-29-6
• Molecular Formula: C₂₃H₂₈O₇
• Molecular Weight: 416.471
• Mol file: 1357899-29-6.mol

Synonyms:3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester

Chemical Property of 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester

There total 2 articles about 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

3-(2-(methoxymethoxy)phenyl)propan-1-ol (900509-51-5) + 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid (1357899-13-8) → 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester (1357899-29-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2011.12.034

Reference yield:

2-methoxy-4-(methoxylmethoxy)benzaldehyde (114628-32-9) → 3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester (1357899-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; aniline / toluene / 24 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; aniline; In dichloromethane; toluene;

DOI:10.1016/j.ejmech.2011.12.034

Reference yield: 62.0%

3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid 3-(2-methoxymethoxyphenyl)propyl ester (1357899-29-6) → 3-(4-hydroxy-2-methoxyphenyl)acrylic acid 3-(2-hydroxyphenyl)propyl ester (1357899-07-0)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 60 ℃; for 24h;

DOI:10.1016/j.ejmech.2011.12.034

upstream raw materials:

3-(2-(methoxymethoxy)phenyl)propan-1-ol

3-(2-methoxy-4-methoxymethoxyphenyl)acrylic acid

2-methoxy-4-(methoxylmethoxy)benzaldehyde

Downstream raw materials:

3-(4-hydroxy-2-methoxyphenyl)acrylic acid 3-(2-hydroxyphenyl)propyl ester