4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate

Base Information

• Chemical Name: 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate
• CAS No.: 133945-18-3
• Molecular Formula: C₂₅H₁₉NO₅
• Molecular Weight: 413.43
• Mol file: 133945-18-3.mol

Synonyms:4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate

Chemical Property of 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate

Chemical Property:

Purity/Quality:

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Technology Process of 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate

There total 3 articles about 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-Cyano-4'-hydroxybiphenyl (19812-93-2) + 4-(2-(acryloyloxy)ethoxy)benzoic acid (69260-38-4) → 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate (133945-18-3)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(dimethylamino)pyridinium tosylate; In dichloromethane; for 3h;

DOI:10.1246/cl.2007.452

Reference yield:

4-(2-hydroxyethoxy)benzoic acid (1711-24-6) → 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate (133945-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / hydroquinone; p-toluenesulfonic acid monohydrate / toluene / 3 h / 130 °C

2: 87 percent / 4-(dimethylamino)pyridinium 4-toluenesulfonate; 2,6-di-tert-butyl-p-cresol; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 3 h

With 2,6-di-tert-butyl-4-methyl-phenol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydroquinone; 4-(dimethylamino)pyridinium tosylate; In dichloromethane; toluene;

DOI:10.1246/cl.2007.452

Reference yield:

4-hydroxy-benzoic acid (99-96-7) → 4-cyanobiphenyl 4-(2-acryloyloxyethyloxy)benzoate (133945-18-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / potassium hydroxide; potassium iodide / H₂O; ethanol / 5 h / 100 °C

2: 82 percent / hydroquinone; p-toluenesulfonic acid monohydrate / toluene / 3 h / 130 °C

3: 87 percent / 4-(dimethylamino)pyridinium 4-toluenesulfonate; 2,6-di-tert-butyl-p-cresol; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 3 h

With potassium hydroxide; 2,6-di-tert-butyl-4-methyl-phenol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydroquinone; 4-(dimethylamino)pyridinium tosylate; potassium iodide; In ethanol; dichloromethane; water; toluene;

DOI:10.1246/cl.2007.452

upstream raw materials:

4-Cyano-4'-hydroxybiphenyl

4-(2-(acryloyloxy)ethoxy)benzoic acid

4-(2-hydroxyethoxy)benzoic acid

4-hydroxy-benzoic acid