1711-24-6

Usage

Uses

Used in Sunscreen Products:
4-(2-HYDROXY-ETHOXY)-BENZOIC ACID is used as a UV filter in sunscreen products for its ability to absorb UVB radiation, providing protection against sunburn and other harmful effects of the sun.
Used in Cosmetic Products:
In the cosmetic industry, 4-(2-HYDROXY-ETHOXY)-BENZOIC ACID is used as a UV filter in various cosmetic products to protect the skin from the damaging effects of the sun while maintaining the product's efficacy and stability.

InChI:InChI=1/C9H10O4/c10-5-6-13-8-3-1-7(2-4-8)9(11)12/h1-4,10H,5-6H2,(H,11,12)

Upstream product

• 75-21-8 oxirane 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 107-07-3 2-chloro-ethanol 
• 99-96-7 4-hydroxy-benzoic acid 
• 540-51-2 2-bromoethanol 
• 1892-43-9 2-(4-chlorophenoxy)ethanol 
• 124-38-9 carbon dioxide 
• 34743-88-9 2-(4-bromophenoxy)ethanol 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 2177-18-6 vinyl acrylate 
• 144-55-8 sodium hydrogencarbonate 
• 150-76-5 4-methoxy-phenol 
• 78-93-3 butanone 
• 652-67-5 Isosorbide 

Downstream Products

• 65136-50-7 4-(2-chloro-ethoxy)-benzoyl chloride 
• 52404-42-9 4-(2-acetoxyethoxy)benzoic acid 
• 96718-98-8 4-(2-Hydroxy-ethoxy)-N-[2-(3-methoxy-phenyl)-ethyl]-N-phenyl-benzamide 
• 69260-38-4 4-(2-(acryloyloxy)ethoxy)benzoic acid 
• 1265966-33-3 C₉H₉IO₄ 
• 864498-64-6 4-(2-undec-10-enoyloxyethoxy)benzoic acid 
• 1422559-81-6 4-hydroxybiphenyl-4'-(2-undec-10-enoyloxyethoxy)benzoate 
• 1124218-92-3 C₂₀H₂₇ClO₄ 
• 1422559-75-8 4-(menthyloxyacetoxy)biphenyl-4'-(2-(undec-10-enoyloxy)ethoxy)benzoate 
• 1422559-77-0 4-(menthyloxyacetoxybenzoyloxy)biphenyl-4'-(2-(undec-10-enoyloxy)ethoxy)benzoate 
• 99-96-7 4-hydroxy-benzoic acid 
• 69260-39-5 4-(2-methylprop-2-enoyloxyethoxy)benzoic acid 

Relevant academic research and scientific papers

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. However, C10a has some pharmacological defects and cytotoxicity. Herein, a structure-based drug design approach was used based on the structure of C10a to elaborate the smaller tricyclic core. A series of tricyclic derivatives were synthesised and the compounds 15, 28 and 34 exhibited the most PTP1B enzymatic inhibitory potency. In the insulin-resistant human hepatoma HepG2 cells, compound 25 with the moderate PTP1B inhibition and preferable pharmaceutical properties can significantly increase insulin-stimulated glucose uptake and showed the insulin resistance ameliorating effect. Moreover, 25 showed the improved in vivo antihyperglycaemic potential in the nicotinamide–streptozotocin-induced T2D. Our study demonstrated that these tricyclic derivatives with improved molecular architectures and antihyperglycaemic activity could be developed in the treatment of T2D.

A biphenyl type acrylate liquid crystal resin synthesis method

The invention discloses biphenyl acrylate liquid crystal resin and a synthetic method thereof. The synthetic method comprises the steps of synthesizing symmetrical and unsaturated liquid crystal resin through an acylation reaction and an esterification reaction by using unsaturated double bonds of acrylic acid; preparing di-ester and biphenyl liquid crystal resin by using the characteristics of 3,3',5,5'-tera-alkyl (or fluoro) biphenol, such as strong rigidity, large intermolecular attraction and conjugation effect of benzene rings. The biphenyl acrylate liquid crystal resin disclosed by the invention has the characteristics of the biphenyl liquid crystal resin, such as no color, generally relatively high clearing point, ultra-high dielectric anisotropy value, good physical and chemical properties, good optical and chemical stability, anisotropy, very wide liquid crystal phase region, adjustable viscosity, birefringence and physical parameters, good molding processing property and the like.

Synthesis, structure, and mesomorphism of novel liquid crystalline acrylate monomers and polymers

A series of novel liquid crystalline monomers (M1-M8) and side chain polymers base polyacrylate backbone were synthesized. The chemical structures were characterized by FT-IR and 1H-NMR spectra. The mesomorphism and thermal behavior was investigated by polarizing optical microscopy, differential scanning calorimetry, and thermogravimetric analysis. The relationships of structure and mesomorphism are discussed in detail. The eight monomers and their corresponding polymers all show enantiotropic nematic phase. With increasing the spacer length or flexibility of the terminal group, the melting temperature (Tm) and isotropic temperature (Ti) of the corresponding monomers and polymers all decreased. However, with increasing the rigidity of the mesogenic core, Tm and Ti of the corresponding monomers and polymers all increased. TGA showed that all the polymers obtained in this study had excellent thermal stability.

A novel soft matter composite material for energy-saving smart windows: From preparation to device application

Nowadays, with the increasing energy consumption of buildings and the continuous improvement of human living standards, use of architectural glass with multi-functional features of large-scale manufacturing, safety and energy saving has become the mainstr

Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers

A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is

Synthesis, structure, and properties of chiral liquid crystal monomers and polymers based on menthol

To study structure-mesomorphism relationships of the monomers and polymers based on menthol, four new chiral monomers (M1-M4) and the corresponding homopolymers (P1-P4) with menthyl group were synthesized. Their chemical structures, formula, phase behavior, and thermal stability were characterized by FTIR, 1H NMR, 13C NMR, elemental analyses, differential scanning calorimetry, polarizing optical microscopy, X-ray diffraction, and thermogravimetric analysis. The selective reflection of light was investigated with ultraviolet/visible spectrometer. The influence of the mesogenic core rigidity, spacer length, and menthyl steric effect on the mesomorphism of M1-M4 and P 1-P4 was examined. By inserting a flexible spacer between the mesogenic core and the terminal menthyl groups, four target monomers and polymers could form the expected mesophase. Moreover, their melting temperature (Tm), glass transition temperature (Tg), clearing temperature (Ti), and mesophase range (δT) increased with increasing the mesogenic core rigidity; whereas the Tm and T g decreased, Ti and δT increased with an increase of the spacer length. M1 and M2 showed monotropic and enantiotropic cholesteric phase, respectively, whereas M3 and M 4 all revealed chiral smectic C (SmC*), cholesteric and cubic blue phases. In addition, with increasing temperature, the selective reflection of light shifted to the long wavelength region at the SmC* phase range and to the short wavelength region at the cholesteric range, respectively. P 1 and P2 only showed a smectic A (SmA) phase, whereas P3 and P4 exhibited the SmC* and SmA phases. All the obtained polymers had very good thermal stability.

Mpg-C3N4-catalyzed selective oxidation of alcohols using O2 and visible light

Mesoporous carbon nitride (mpg-C3N4) polymer can function as a metal-free photocatalyst to activate O2 for the selective oxidation of benzyl alcohols with visible light, avoiding the cost, toxicity, and purification problems associated with corresponding transition-metal systems. By combining the surface basicity and semiconductor functions of mpg-C3N4, the photocatalytic system can realize a high catalytic selectivity to generate benzaldehyde. The metal-free photocatalytic system also selectively converts other alcohol substrates to their corresponding aldehydes/ketones, demonstrating a potential pathway of accessing traditional mild radical chemistry with nitroxyl radicals.

DIOXETANE COMPOUND, CATIONICALLY POLYMERIZABLE COMPOSITION, OPTICAL FILM AND LIQUID CRYSTAL DISPLAY UNIT

The present invention provides a novel dioxetane compound having a cationically polymerizable oxetane group, which compound is excellent in compatibility with a liquid crystalline compound and a non-liquid crystalline compound. The present invention also provides an optical film with excellent liquid crystal orientation retention properties and mechanical strength, produced by aligning a composition of the dioxetane compound and a cationically polymerizable compound in a liquid crystal orientation and fixing the liquid crystal orientation by polymerization, and a liquid crystal display device with the optical film.

Facile synthesis of novel monodisperse liquid-crystalline oligomers based on Michael adducts from millipede cyanoacetates

Facile synthesis of novel monodisperse liquid-crystalline (LC) oligomers was performed. The functionalization of the end group of 4 (and 6) millipede cyanoacetates with 8 (and 12) mesogenic units by Michael addition reaction produced a monodisperse LC oct

PYRROLIDINE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.