3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile

Base Information

• Chemical Name: 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile
• CAS No.: 78564-36-0
• Molecular Formula: C₂₁H₁₅N₃OS
• Molecular Weight: 357.436

Synonyms:3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile

Chemical Property of 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile

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Technology Process of 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile

There total 13 articles about 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-cyano-4-phenyl-6-p-methylphenyl-pyridin-2(1H)-thione (78564-19-9) + chloroacetonitrile (107-14-2) → 3-Amino-4-phenyl-6-p-tolyl-thieno[2,3-b]pyridine-2-carbonitrile (78564-37-1) + 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile (78564-36-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1007/BF00505994

Reference yield: 55.0%

4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (58327-74-5) + methyl chloroacetate (96-34-4) → 3-Amino-4,6-diphenyl-thieno<2,3-b>pyridin-2-carbonsaeuremethylester (78564-38-2) + 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile (78564-36-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1007/BF00505994

Reference yield: 42.0%

6-(4-methoxyphenyl)-4-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (78564-18-8) + chloroacetonitrile (107-14-2) → 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile (78564-36-0) + 2-Cyanomethylsulfanyl-6-(4-methoxy-phenyl)-4-phenyl-nicotinonitrile (78564-28-0)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 15 - 20 ℃; for 0.5h;

DOI:10.1007/BF00505994

upstream raw materials:

2-Cyanomethylsulfanyl-6-(4-methoxy-phenyl)-4-phenyl-nicotinonitrile

3-cyano-4-phenyl-6-p-methylphenyl-pyridin-2(1H)-thione

chloroacetonitrile

6-(4-methoxyphenyl)-4-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile

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