Technology Process of (Z)-2-benzyl-2,3-dihydro-3-(phenylmethylene)-1H-pyrrolo[3,4-c]pyridin-1-one
There total 3 articles about (Z)-2-benzyl-2,3-dihydro-3-(phenylmethylene)-1H-pyrrolo[3,4-c]pyridin-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro bis(acetonitrile) palladium(II); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 0.5h;
stereoselective reaction;
Inert atmosphere;
Microwave irradiation;
DOI:10.1016/j.tetlet.2011.08.070
- Guidance literature:
-
Multi-step reaction with 3 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / benzene / 0.5 h / Inert atmosphere
2: triethylamine / dichloromethane / 1 h / Inert atmosphere
3: dichloro bis(acetonitrile) palladium(II); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
With
dichloro bis(acetonitrile) palladium(II); oxalyl dichloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide;
In
dichloromethane; N,N-dimethyl-formamide; benzene;
3: Sonogashira coupling/5-exo-dig cycloisomerization domino reaction;
DOI:10.1016/j.tetlet.2011.08.070
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 1 h / Inert atmosphere
2: dichloro bis(acetonitrile) palladium(II); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation
With
dichloro bis(acetonitrile) palladium(II); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
2: Sonogashira coupling/5-exo-dig cycloisomerization domino reaction;
DOI:10.1016/j.tetlet.2011.08.070
