methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate
CAS No.:1198593-06-4
Molecular Formula:C₃₁H₃₂N₂O₄
Molecular Weight:496.606
Hs Code.:

Synonyms:methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

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Chemical Property of methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

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Technology Process of methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

There total 9 articles about methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1198593-03-1
methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

: 1198593-06-4
methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate; With osmium(VIII) oxide; In 1,4-dioxane; water; tert-butyl alcohol; for 0.0333333h;

With sodium periodate; In 1,4-dioxane; water; tert-butyl alcohol; at 20 ℃; for 48h;

Reference yield:

: 860457-92-7
methyl 3-bromo-1H-indazole-6-carboxylate

: 1198593-06-4
methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap / tetrahydrofuran / 16 h / 20 °C

2.1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

3.1: hydrogenchloride / ethyl acetate

4.1: caesium carbonate / acetonitrile / 2 h / Reflux

5.1: hydrazine hydrate / methanol / 16 h / 75 °C

6.1: HATU / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C

7.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 70 °C

8.1: N-Bromosuccinimide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.37 h / 120 °C / Irradiation with 150 W microwave

9.1: osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 0.03 h

9.2: 48 h / 20 °C

With hydrogenchloride; dmap; N-Bromosuccinimide; osmium(VIII) oxide; caesium carbonate; hydrazine hydrate; HATU; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 479552-81-3
3-bromoindole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

: 1198593-06-4
methyl 2-formyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

2.1: hydrogenchloride / ethyl acetate

3.1: caesium carbonate / acetonitrile / 2 h / Reflux

4.1: hydrazine hydrate / methanol / 16 h / 75 °C

5.1: HATU / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C

6.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 70 °C

7.1: N-Bromosuccinimide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.37 h / 120 °C / Irradiation with 150 W microwave

8.1: osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 0.03 h

8.2: 48 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; osmium(VIII) oxide; caesium carbonate; hydrazine hydrate; HATU; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;