methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate
CAS No.:1198593-03-1
Molecular Formula:C₃₂H₃₄N₂O₃
Molecular Weight:494.634
Hs Code.:

Synonyms:methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

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Chemical Property of methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

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Technology Process of methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

There total 9 articles about methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1198593-02-0
methyl 2-bromo-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1198593-03-1
methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: With N-Bromosuccinimide; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.366667h; Irradiation with 150 W microwave;

Reference yield:

: 860457-92-7
methyl 3-bromo-1H-indazole-6-carboxylate

: 1198593-03-1
methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: dmap / tetrahydrofuran / 16 h / 20 °C

2: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

3: hydrogenchloride / ethyl acetate

4: caesium carbonate / acetonitrile / 2 h / Reflux

5: hydrazine hydrate / methanol / 16 h / 75 °C

6: triethylamine / dichloromethane / 1.5 h / 20 °C

7: N-Bromosuccinimide / tetrahydrofuran / 3 h / 70 °C

8: N-Bromosuccinimide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.37 h / 120 °C / Irradiation with 150 W microwave

With hydrogenchloride; dmap; N-Bromosuccinimide; caesium carbonate; hydrazine hydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 479552-81-3
3-bromoindole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

: 1198593-03-1
methyl 2-ethenyl-1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

2: hydrogenchloride / ethyl acetate

3: caesium carbonate / acetonitrile / 2 h / Reflux

4: hydrazine hydrate / methanol / 16 h / 75 °C

5: HATU / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C

6: N-Bromosuccinimide / tetrahydrofuran / 3 h / 70 °C

7: N-Bromosuccinimide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.37 h / 120 °C / Irradiation with 150 W microwave

With hydrogenchloride; N-Bromosuccinimide; caesium carbonate; hydrazine hydrate; HATU; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;