4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone

Base Information

• Chemical Name: 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone
• CAS No.: 103680-84-8
• Molecular Formula: C₁₉H₂₂O₅
• Molecular Weight: 330.381
• Mol file: 103680-84-8.mol

Synonyms:4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone

Chemical Property of 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone

There total 2 articles about 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2',4'-dihydroxy-α,β-dihydrochalcone (53596-71-7) + ethyl chloromethyl ether (3188-13-4) → 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone (103680-84-8)

Guidance literature:

With potassium carbonate; In acetone; 1.) rt.; 2.) 40 deg C, 15 min, then 60 deg C, 3h;

DOI:10.1016/S0040-4020(01)91433-4

Reference yield:

(2E)-1-[4-(benzyloxy)-2-hydroxyphenyl]-3-phenylprop-2-en-1-one (24532-21-6,872131-45-8) → 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone (103680-84-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.3 g / H₂ / palladised charcoal / ethyl acetate

2: 92 percent / K₂CO₃ / acetone / 1.) rt.; 2.) 40 deg C, 15 min, then 60 deg C, 3h

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; acetone;

DOI:10.1016/S0040-4020(01)91433-4

Reference yield: 38.0%

4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone (103680-84-8) → 3-benzyl-7-ethoxymethoxy-4-chromanone (103680-86-0)

Guidance literature:

With sodium carbonate; In ethanol; for 3h; Heating;

DOI:10.1016/S0040-4020(01)91433-4

upstream raw materials:

2',4'-dihydroxy-α,β-dihydrochalcone

ethyl chloromethyl ether

(2E)-1-[4-(benzyloxy)-2-hydroxyphenyl]-3-phenylprop-2-en-1-one

Downstream raw materials:

3-benzyl-7-ethoxymethoxy-4-chromanone

3-benzyl-7-hydroxy-4-chromanone

Refernces