53596-71-7

Usage

General Description

2',4'-dihydroxy-4-methoxydihydrochalcone is a chemical compound found in plants such as Angelica keiskei, also known as ashitaba. It is classified as a chalcone, a type of flavonoid compound. 2',4'-DIHYDROXY-4-METHOXYDIHYDROCHALCONE has shown antioxidant, anti-inflammatory, and anti-cancer properties in various studies. It has potential therapeutic effects on various health conditions such as obesity, diabetes, and cardiovascular diseases. Additionally, it has been studied for its potential use in skincare and cosmetic products due to its antioxidant and anti-aging properties. Overall, 2',4'-dihydroxy-4-methoxydihydrochalcone shows promising potential for various health and cosmetic applications.

Upstream product

• 645-45-4 hydrocinnamic acid chloride 
• 108-46-3 recorcinol 
• 119-64-2 tetralin 
• 6665-86-7 7-hydroxyflavone 
• 102-93-2 3-phenylpropionamide 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 100-52-7 benzaldehyde 
• 1776-30-3 (E)-2',4'-dihydroxychalcone 
• 4192-77-2 ethyl cinnamate 
• 112-92-5 1-octadecanol 
• 24532-21-6 (2E)-1-[4-(benzyloxy)-2-hydroxyphenyl]-3-phenylprop-2-en-1-one 
• 501-52-0 3-Phenylpropionic acid 
• 645-59-0 dihydrocinnamonitrile 

Downstream Products

• 151895-76-0 3-benzyl-7-hydroxy-4H-chromen-4-one 
• 6665-86-7 7-hydroxyflavone 
• 128995-85-7 6-[4-(1-(2,4-dihydroxyphenyl)-3-phenylpropylidene)-aminophenyl]-4,5-dihydropyridazin-3(2H)one 
• 103680-86-0 3-benzyl-7-ethoxymethoxy-4-chromanone 
• 103680-88-2 3-benzyl-7-hydroxy-4-chromanone 
• 103680-84-8 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyldihydrochalcone 
• 110690-70-5 3-benzyl-7-hydroxy-2-methyl-chromen-4-one 

Relevant academic research and scientific papers

Synthesis and biological activity of (±)-7,3′,4′-trihydroxyhomoisoflavan and its analogs

Acetylcholinesterase (AChE) inhibitors and neurite outgrowth promoters are thought to alleviate the symptoms of degenerative brain disorders, such as Alzheimer's disease. We designed and synthesized a series of homoisoflavonoids based on the structure of natural homoisoflavan isolated from Dracaena cambodiana dragon's blood. The homoisoflavonoids were then evaluated as AChE inhibitors and neurite outgrowth promoters. The catechol structure of the homoisoflavan B rings was important for AChE inhibition, and some of the homoisoflavonoids significantly promoted neurite outgrowth induced by nerve growth factor (NGF).

Single and double intramolecular proton transfers in the electronically excited state of flavone derivatives

In an attempt to create a flavone derivative able to take part in Excited State Intramolecular Double Proton Transfer (ESIDPT), we synthesized two carbonyl derivatives of 3,7-dihydroxyflavone, both containing two different proton-transfer sites as well as related carbonyl derivatives of 3-hydroxyflavone and 7-hydroxyflavone. All the examined hydroxyflavones were found to participate in the Excited State Intramolecular Proton Transfer (ESIPT). ESIPT which involves 3-hydroxyl and 4-carbonyl groups was found to have a higher barrier compared to ESIPT involving 7-hydroxyl and 6/8-carbonyl fragments. According to the data presented, 3,7-dihydroxy-2-phenyl-6-(3-phenylpropanoyl)-4H-chromen-4-one undergoes a two-stage ESIDPT with formation of an intermediate tautomer. This kind of ESIDPT leads to a tautomeric form with an abnormally low rate of radiative deactivation of the excited state, which conditions low fluorescence quantum yield. The behavior of 3,7-dihydroxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde in the electronically excited state is similar to 3-hydroxyflavone derivatives, thus we conclude the occurrence of a single ESIPT in this compound.

Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW ～ 205.19, λab ～ 350 nm, λem ～ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues. This journal is

A NEW SYNTHESIS OF HOMOISOFLAVANONES (3-BENZYL-4-CHROMANONES)

Two 7-hydroxyhomoisoflavanones (6a/6b) have been synthesized from corresponding 2'-hydroxydihydrochalcones (2a/2b) in about 33percent overall yields.The stages are : (i) selective protection of C4'-hydroxyl in 2a/2b with EtO.CH2Cl (1 molar equiv.) in the