2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

Base Information

Chemical Name:2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid
CAS No.:1390638-09-1
Molecular Formula:C₂₄H₁₇F₃O₅
Molecular Weight:442.391
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

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Chemical Property of 2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

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Technology Process of 2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

There total 4 articles about 2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 385395-06-2
C₂₆H₂₁F₃O₅

: 1390638-09-1
2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

Guidance literature:: C₂₆H₂₁F₃O₅; With sodium hydroxide; In ethanol; water; at 50 ℃; for 0.166667h; Microwave irradiation; Sealed vessel;

With hydrogenchloride; In ethanol; water; Cooling with ice;
DOI:10.1016/j.bmc.2012.05.074

Reference yield:

: 5010-38-8
ethyl 5-hydroxy-2-(4-methoxyphenyl)-1-benzofuran-3-carboxylate

: 1390638-09-1
2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 80 °C

2.1: sodium hydroxide / ethanol; water / 0.17 h / 50 °C / Microwave irradiation; Sealed vessel

2.2: Cooling with ice

With potassium carbonate; sodium hydroxide; In ethanol; water; acetone;
DOI:10.1016/j.bmc.2012.05.074

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 1390638-09-1
2-(4-methoxyphenyl)-5-([3-(trifluoromethyl)benzyl]oxy)-1-benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / Reflux

2.1: zinc(II) chloride / dichloromethane / 0.5 h / 110 °C / Microwave irradiation; Sealed vessel

3.1: potassium carbonate / acetone / 80 °C

4.1: sodium hydroxide / ethanol; water / 0.17 h / 50 °C / Microwave irradiation; Sealed vessel

4.2: Cooling with ice

With sodium hydride; potassium carbonate; sodium hydroxide; zinc(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1016/j.bmc.2012.05.074