4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

Base Information

Chemical Name:4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol
CAS No.:1307854-04-1
Molecular Formula:C₂₆H₄₀OSi
Molecular Weight:396.689
Hs Code.:

Synonyms:4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

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Chemical Property of 4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

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Technology Process of 4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

There total 4 articles about 4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1307853-96-8
[(3,5-diethyl-4-iodophenyl)ethynyl]triisopropylsilane

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1307854-04-1
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1002/ejoc.201001531

Reference yield:

: 1307853-89-9
2,6-diethyl-4-[(triisopropylsilyl)ethynyl]aniline

: 1307854-04-1
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 3 °C

1.2: 2 h / 0 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; water; 1.1: Sandmeyer type reaction / 1.2: Sandmeyer type reaction / 2.1: Sonogashira coupling;
DOI:10.1002/ejoc.201001531

Reference yield:

: 579-66-8
2,6-diethylaniline

: 1307854-04-1
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; sodium hydrogencarbonate / methanol; water / 0 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 72 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 3 °C

3.2: 2 h / 0 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; methanol; water; 2.1: Sonogashira coupling / 3.1: Sandmeyer type reaction / 3.2: Sandmeyer type reaction / 4.1: Sonogashira coupling;
DOI:10.1002/ejoc.201001531