4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

Base Information

Chemical Name:4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole
CAS No.:1307854-23-4
Molecular Formula:C₂₇H₄₃N₃Si
Molecular Weight:437.744
Hs Code.:

Synonyms:4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

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Chemical Property of 4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

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Technology Process of 4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

There total 6 articles about 4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 78-77-3
Isobutyl bromide

: 1307854-12-1
[(3,5-diethyl-4-ethynylphenyl)ethynyl]triisopropylsilane

: 1307854-23-4
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

Guidance literature:: Isobutyl bromide; With sodium azide; In N,N-dimethyl-formamide; at 50 ℃; for 15h;

[(3,5-diethyl-4-ethynylphenyl)ethynyl]triisopropylsilane; With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In methanol; water; N,N-dimethyl-formamide; at 50 ℃; for 120h;
DOI:10.1002/ejoc.201001531

Reference yield:

: 1307853-96-8
[(3,5-diethyl-4-iodophenyl)ethynyl]triisopropylsilane

: 1307854-23-4
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / toluene / 3 h / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 15 h / 50 °C

3.2: 120 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1.1: Sonogashira coupling;
DOI:10.1002/ejoc.201001531

Reference yield:

: 1307854-04-1
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-2-methylbut-3-yn-2-ol

: 1307854-23-4
4-{2,6-diethyl-4-[(triisopropylsilyl)ethynyl]phenyl}-1-isobutyl-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / toluene / 3 h / Reflux

2.1: sodium azide / N,N-dimethyl-formamide / 15 h / 50 °C

2.2: 120 h / 50 °C

With sodium azide; sodium hydroxide; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/ejoc.201001531