4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

Base Information

Chemical Name:4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide
CAS No.:188397-81-1
Molecular Formula:C₁₈H₁₂F₅N₃O
Molecular Weight:381.305
Hs Code.:

Synonyms:4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

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Technology Process of 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

There total 9 articles about 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 188397-79-7
(4-Fluoro-phenyl)-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-methanone

: 2-(4-Fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazole-4-carboxylic acid (4-fluoro-phenyl)-amide

: 188397-81-1
4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

Guidance literature:: With sodium azide; sulfuric acid; In hexane; 0 deg C, 2 h, rt, 2 d;
DOI:10.1021/jo961723x

Reference yield:

: 49854-61-7
4-fluoro-N-<2,2,2-trifluoro-1-(trifluoromethyl)ethylidene>benzamide

: 188397-81-1
4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2.) H₂O₂, NaOH / 1.)Et₂O, rt, overnight, 2.) MeOH, H₂O, rt, 2 h

2: 76 percent / NaH / dimethylformamide / 2 h

3: 100 percent / DIBAL-H / tetrahydrofuran / 2 h / Heating

4: 13 percent / dimethylsulfoxide / 2 h / 70 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h, 23 deg C, 1 h

6: PCC / CH₂Cl₂ / Ambient temperature

7: 70 percent / NaN₃, H₂SO₄ / hexane / 0 deg C, 2 h, rt, 2 d

With sodium hydroxide; n-butyllithium; sodium azide; sulfuric acid; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo961723x

Reference yield:

: 188397-74-2
2-(4-Fluoro-phenyl)-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-4-one

: 188397-81-1
4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5-trifluoromethyl-3H-imidazol-4-yl]-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / NaH / dimethylformamide / 2 h

2: 100 percent / DIBAL-H / tetrahydrofuran / 2 h / Heating

3: 13 percent / dimethylsulfoxide / 2 h / 70 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h, 23 deg C, 1 h

5: PCC / CH₂Cl₂ / Ambient temperature

6: 70 percent / NaN₃, H₂SO₄ / hexane / 0 deg C, 2 h, rt, 2 d

With n-butyllithium; sodium azide; sulfuric acid; sodium hydride; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo961723x