4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• CAS No.: 301672-94-6
• Molecular Formula: C₂₉H₃₉ClN₂O₃
• Molecular Weight: 499.093

Synonyms:4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of 4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

There total 5 articles about 4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-methyl]phosphonic acid, dimethyl ester + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (301672-94-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

4-[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methyl]phosphonic acid dimethyl ester + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (301672-94-6)

Guidance literature:

4-[[4-chloro-3-[[(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methyl]phosphonic acid dimethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; for 24h; Further stages.;

DOI:10.1021/jm700949w

Reference yield:

5-bromomethyl-2-chloro-benzoic acid (66658-57-9) → 4-[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester (301672-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N-methyl-acetamide; dichloromethane

2: phosphorous acid trimethyl ester

3: lithium diisopropyl amide / tetrahydrofuran; methanol; dichloromethane

With N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; N-methyl-acetamide; methanol; dichloromethane; phosphorous acid trimethyl ester;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

5-bromomethyl-2-chloro-benzoic acid

5-bromomethyl-2-chloro-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)-benzamide

2-chloro-5-methyl-benzoic acid

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