Technology Process of tert-butyl ethyl(4-methoxybenzyl)carbamate
There total 3 articles about tert-butyl ethyl(4-methoxybenzyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl ethyl(methyl)carbamate;
With
N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
In
diethyl ether; cyclohexane;
at -60 ℃;
for 1h;
Inert atmosphere;
With
zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; cyclohexane;
at -60 - 20 ℃;
for 1.5h;
Inert atmosphere;
1-bromo-4-methoxy-benzene;
With
tris-(dibenzylideneacetone)dipalladium(0); PtBu3*HBF4;
In
toluene;
at 25 ℃;
for 17h;
Inert atmosphere;
DOI:10.1002/anie.201310904
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 1 h / -60 °C
1.2: 0.5 h / -60 °C
2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 1 h / -60 °C / Inert atmosphere
2.2: 1.5 h / -60 - 20 °C / Inert atmosphere
2.3: 17 h / 25 °C / Inert atmosphere
With
N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
In
diethyl ether; cyclohexane;
DOI:10.1002/anie.201310904
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / water; tetrahydrofuran / 6.17 h / 0 - 20 °C
2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 1 h / -60 °C
2.2: 0.5 h / -60 °C
3.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 1 h / -60 °C / Inert atmosphere
3.2: 1.5 h / -60 - 20 °C / Inert atmosphere
3.3: 17 h / 25 °C / Inert atmosphere
With
N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; triethylamine;
In
tetrahydrofuran; diethyl ether; cyclohexane; water;
DOI:10.1002/anie.201310904
