1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Base Information

Chemical Name:1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester
CAS No.:111496-31-2
Molecular Formula:C₄₁H₄₇N₂O₈P
Molecular Weight:726.807
Hs Code.:

Synonyms:1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

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Chemical Property of 1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

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Technology Process of 1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

There total 6 articles about 1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42491-84-9
(S)-6-Amino-2-hydroxyhexanoic acid

: 111496-31-2
1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. NaOH / 45 h / 0 °C / pH 10

2: 94 percent / Et₃N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C_. 3 h, 2.) room temperature, 1 h

3: Et₃N, DMAP / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h

With dmap; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00396a033

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 111496-31-2
1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C_. 3 h, 2.) room temperature, 1 h

2: Et₃N, DMAP / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h

With dmap; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00396a033

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 111496-31-2
1-<(S)-2-<<(phenylmethoxy)(2-phenethyl)phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. NaOH / 45 h / 0 °C / pH 10

2: 94 percent / Et₃N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C_. 3 h, 2.) room temperature, 1 h

3: Et₃N, DMAP / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h

With dmap; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00396a033