(+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide

Base Information

• Chemical Name: (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide
• CAS No.: 400781-21-7
• Molecular Formula: C₁₇H₁₆O₄
• Molecular Weight: 284.312
• Mol file: 400781-21-7.mol

Synonyms:(+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide

Chemical Property of (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide

There total 5 articles about (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

7-methoxyisobenzofuran-1(3H)-one (28281-58-5) + p-Methoxybenzyl bromide (2746-25-0) → (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide (400781-21-7)

Guidance literature:

7-methoxyisobenzofuran-1(3H)-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

p-Methoxybenzyl bromide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Further stages.;

DOI:10.1039/b106268a

Reference yield:

7-methoxy-3-((Ξ)-4-methoxy-benzylidene)-phthalide → (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide (400781-21-7)

Guidance literature:

With potassium hydroxide; anschliessend Behandeln mit Natrium-Amalgam und Wasser und Ansaeuern der Reaktionsloesung;

DOI:10.1361/105994900770345809

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → (+/-)-3-(4-methoxybenzyl)-7-methoxyphthalide (400781-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / 220 °C

2: methanol. KOH-solution / anschliessend Behandeln mit Natrium-Amalgam und Wasser und Ansaeuern der Reaktionsloesung

With potassium hydroxide; sodium acetate;

DOI:10.1361/105994900770345809

upstream raw materials:

7-methoxyisobenzofuran-1(3H)-one

p-Methoxybenzyl bromide

4-Methoxyphenylacetic acid

3-methoxyphthalic anhydride

Downstream raw materials:

(+/-)-3-(4-methoxyphenyl)-8-hydroxy-3,4-dihydroisocoumarin