1,3-Isobenzofurandione,4-methoxy-(9CI)

Base Information

• Chemical Name: 1,3-Isobenzofurandione,4-methoxy-(9CI)
• CAS No.: 14963-96-3
• Molecular Formula: C9H6 O4
• Molecular Weight: 178.144
• Hs Code.: 2932999099
• Mol file: 14963-96-3.mol

Synonyms:Phthalicanhydride, 3-methoxy- (6CI,7CI,8CI); 3-Methoxyphthalic anhydride;4-Methoxyisobenzofuran-1,3-dione; NSC 156146; NSC 239373

Chemical Property of 1,3-Isobenzofurandione,4-methoxy-(9CI)

Chemical Property:

• Vapor Pressure: 3.97E-05mmHg at 25°C
• Boiling Point: 351.9°Cat760mmHg
• Flash Point: 160.6°C
• PSA: 52.60000
• Density: 1.407g/cm³
• LogP: 1.00580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxyisobenzofuran-1,3-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Methoxyisobenzofuran-1,3-dione is used as a reactant in the preparation of potent nonpeptide angiotensin II receptor antagonists.

Technology Process of 1,3-Isobenzofurandione,4-methoxy-(9CI)

There total 2 articles about 1,3-Isobenzofurandione,4-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethylanisole (2944-49-2) → 3-methoxyphthalic anhydride (14963-96-3) + 3-methoxyphthalic acid (14963-97-4)

Guidance literature:

2,3-dimethylanisole; With potassium permanganate; In water; tert-butyl alcohol; for 6h; Reflux;

With hydrogenchloride; In water; tert-butyl alcohol;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + N,N-diethyl-3-methoxybenzamide (62924-93-0) → 3-methoxyphthalic anhydride (14963-96-3) + N,N-diethyl 2-carboxy-3-methoxybenzamide (70946-14-4)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h;

DOI:10.1016/S0040-4020(01)81579-9

Reference yield: 75.0%

3-methoxyphthalic anhydride (14963-96-3) + benzylamine (100-46-9) → 2-benzyl-4-methoxy-1H-isoindole-1,3(2H)-dione

Guidance literature:

With acetic acid; for 48h; Reflux;

DOI:10.3390/molecules25173868

upstream raw materials:

carbon dioxide

N,N-diethyl-3-methoxybenzamide

2,3-dimethylanisole

Downstream raw materials:

7-methoxy-3-((Ξ)-veratrylidene)-phthalide

2-(2-hydroxy-4-methyl-benzoyl)-3-methoxy-benzoic acid

4-methoxy-isoindole-1,3-dione

4-methoxyphthalide