5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole

Base Information

• Chemical Name: 5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole
• CAS No.: 871584-44-0
• Molecular Formula: C₁₁H₈F₄IN₃
• Molecular Weight: 385.103
• Mol file: 871584-44-0.mol

Synonyms:5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole

Chemical Property of 5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole

There total 2 articles about 5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetyl chloride (75-36-5) + phenylacetylene (536-74-3) + 2,2,3,3-tetrafluoropropanyl azide (846057-93-0) → 5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole (871584-44-0) + 4-acetyl-5-phenyl-3-(2,2,3,3-tetrafluoropropyl)-3H-[1,2,3]triazole

Guidance literature:

With copper(l) iodide; 4 A molecular sieve; triethylamine; In tetrahydrofuran; at 20 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1055/s-2005-861860

Reference yield:

phenylacetylene (536-74-3) + 2,2,3,3-tetrafluoropropanyl azide (846057-93-0) → 5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole (871584-44-0) + 4-phenyl-1-(2,2,3,3-tetrafluoro-propyl)-1H-[1,2,3]triazole

Guidance literature:

With copper(l) iodide; iodine; triethylamine; In acetonitrile; at 20 ℃; for 20h; Further Variations:; Reagents; Solvents; Product distribution;

DOI:10.1055/s-2005-861860

Reference yield: 92.0%

5-iodo-4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-[1,2,3]triazole (871584-44-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-3-[4-phenyl-1-(2,2,3,3-tetrafluoropropyl)-1H-1,2,3-triazol-5-yl]acrylic acid methyl ester

Guidance literature:

With tetrabutylammomium bromide; sodium hydrogencarbonate; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1055/s-2005-872119

upstream raw materials:

acetyl chloride

phenylacetylene

2,2,3,3-tetrafluoropropanyl azide