Technology Process of diethyl 2-Acetamido-2-[2-(2-octylphenyl)ethyl]malonate
There total 12 articles about diethyl 2-Acetamido-2-[2-(2-octylphenyl)ethyl]malonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: Mg / tetrahydrofuran / 1 h / 40 °C
1.2: 49 percent / tetrahydrofuran / 1 h / 20 °C
2.1: 82 percent / P2O5 / benzene / 2 h / Heating
3.1: Mg / tetrahydrofuran / 0.5 h / 50 °C
3.2: 88 percent / tetrahydrofuran / 15 h / 20 °C
4.1: 82 percent / H2 / 5percent Pd/C / ethanol / 4 h
5.1: Triton B / methanol; dioxane / 2 h / 80 °C
6.1: HCl / 0.5 h / 20 °C
7.1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
8.1: Et3N / CH2Cl2 / 1 h / 20 °C
9.1: NaI / butan-2-one / 2 h / Heating
10.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
10.2: ethanol / 3 h / 65 °C
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium ethanolate; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; magnesium; triethylamine; sodium iodide;
5percent Pd/C;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; butanone; benzene;
1.1: Metallation / 1.2: Grignard reaction / 2.1: Dehydration / 3.1: Metallation / 3.2: Formylation / 4.1: Catalytic hydrogenation / 5.1: Knoevenagel condensation / 6.1: ethanolysis / 7.1: Reduction / 8.1: mesylation / 9.1: Iodination / 10.1: Metallation / 10.2: Alkylation;
DOI:10.1021/jm000173z
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: Mg / tetrahydrofuran / 1 h / 40 °C
1.2: 49 percent / tetrahydrofuran / 1 h / 20 °C
2.1: 82 percent / P2O5 / benzene / 2 h / Heating
3.1: Mg / tetrahydrofuran / 0.5 h / 50 °C
3.2: 88 percent / tetrahydrofuran / 15 h / 20 °C
4.1: 82 percent / H2 / 5percent Pd/C / ethanol / 4 h
5.1: Triton B / methanol; dioxane / 2 h / 80 °C
6.1: HCl / 0.5 h / 20 °C
7.1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
8.1: Et3N / CH2Cl2 / 1 h / 20 °C
9.1: NaI / butan-2-one / 2 h / Heating
10.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
10.2: ethanol / 3 h / 65 °C
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium ethanolate; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; magnesium; triethylamine; sodium iodide;
5percent Pd/C;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; butanone; benzene;
1.1: Metallation / 1.2: Grignard reaction / 2.1: Dehydration / 3.1: Metallation / 3.2: Formylation / 4.1: Catalytic hydrogenation / 5.1: Knoevenagel condensation / 6.1: ethanolysis / 7.1: Reduction / 8.1: mesylation / 9.1: Iodination / 10.1: Metallation / 10.2: Alkylation;
DOI:10.1021/jm000173z
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: Mg / tetrahydrofuran / 0.5 h / 50 °C
1.2: 88 percent / tetrahydrofuran / 15 h / 20 °C
2.1: 82 percent / H2 / 5percent Pd/C / ethanol / 4 h
3.1: Triton B / methanol; dioxane / 2 h / 80 °C
4.1: HCl / 0.5 h / 20 °C
5.1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
6.1: Et3N / CH2Cl2 / 1 h / 20 °C
7.1: NaI / butan-2-one / 2 h / Heating
8.1: sodium ethoxide / ethanol / 0.5 h / 20 °C
8.2: ethanol / 3 h / 65 °C
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium ethanolate; N-benzyl-trimethylammonium hydroxide; magnesium; triethylamine; sodium iodide;
5percent Pd/C;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; butanone;
1.1: Metallation / 1.2: Formylation / 2.1: Catalytic hydrogenation / 3.1: Knoevenagel condensation / 4.1: ethanolysis / 5.1: Reduction / 6.1: mesylation / 7.1: Iodination / 8.1: Metallation / 8.2: Alkylation;
DOI:10.1021/jm000173z
