2-octylphenethyl iodide

Base Information

Chemical Name:2-octylphenethyl iodide
CAS No.:162358-96-5
Molecular Formula:C₁₆H₂₅I
Molecular Weight:344.279
Hs Code.:

Synonyms:2-octylphenethyl iodide

Suppliers and Price of 2-octylphenethyl iodide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-?(2-?Iodoethyl)?-?2-?octylbenzene
5mg
$ 745.00

American Custom Chemicals Corporation
FINGOLIMOD IMPURITY 2 95.00%
5MG
$ 451.77

Total 4 raw suppliers

Chemical Property of 2-octylphenethyl iodide

Chemical Property:

Purity/Quality:

> 95% ^*data from raw suppliers

1-?(2-?Iodoethyl)?-?2-?octylbenzene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-?(2-?Iodoethyl)?-?2-?octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).

Technology Process of 2-octylphenethyl iodide

There total 11 articles about 2-octylphenethyl iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 629-04-9
1-Bromoheptane

: 162358-96-5
2-octylphenethyl iodide

Guidance literature:: Multi-step reaction with 9 steps

1.1: Mg / tetrahydrofuran / 1 h / 40 °C

1.2: 49 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 82 percent / P₂O₅ / benzene / 2 h / Heating

3.1: Mg / tetrahydrofuran / 0.5 h / 50 °C

3.2: 88 percent / tetrahydrofuran / 15 h / 20 °C

4.1: 82 percent / H₂ / 5percent Pd/C / ethanol / 4 h

5.1: Triton B / methanol; dioxane / 2 h / 80 °C

6.1: HCl / 0.5 h / 20 °C

7.1: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

8.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

9.1: NaI / butan-2-one / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; magnesium; triethylamine; sodium iodide; 5percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; butanone; benzene; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Dehydration / 3.1: Metallation / 3.2: Formylation / 4.1: Catalytic hydrogenation / 5.1: Knoevenagel condensation / 6.1: ethanolysis / 7.1: Reduction / 8.1: mesylation / 9.1: Iodination;
DOI:10.1021/jm000173z

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 162358-96-5
2-octylphenethyl iodide

Guidance literature:: Multi-step reaction with 9 steps

1.1: Mg / tetrahydrofuran / 1 h / 40 °C

1.2: 49 percent / tetrahydrofuran / 1 h / 20 °C

2.1: 82 percent / P₂O₅ / benzene / 2 h / Heating

3.1: Mg / tetrahydrofuran / 0.5 h / 50 °C

3.2: 88 percent / tetrahydrofuran / 15 h / 20 °C

4.1: 82 percent / H₂ / 5percent Pd/C / ethanol / 4 h

5.1: Triton B / methanol; dioxane / 2 h / 80 °C

6.1: HCl / 0.5 h / 20 °C

7.1: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

8.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

9.1: NaI / butan-2-one / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; phosphorus pentoxide; N-benzyl-trimethylammonium hydroxide; magnesium; triethylamine; sodium iodide; 5percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; butanone; benzene; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Dehydration / 3.1: Metallation / 3.2: Formylation / 4.1: Catalytic hydrogenation / 5.1: Knoevenagel condensation / 6.1: ethanolysis / 7.1: Reduction / 8.1: mesylation / 9.1: Iodination;
DOI:10.1021/jm000173z

Reference yield:

: 162358-91-0
1-bromo-2-[(E)-oct-1-enyl]benzene

: 162358-96-5
2-octylphenethyl iodide

Guidance literature:: Multi-step reaction with 7 steps

1.1: Mg / tetrahydrofuran / 0.5 h / 50 °C

1.2: 88 percent / tetrahydrofuran / 15 h / 20 °C

2.1: 82 percent / H₂ / 5percent Pd/C / ethanol / 4 h

3.1: Triton B / methanol; dioxane / 2 h / 80 °C

4.1: HCl / 0.5 h / 20 °C

5.1: LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

6.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

7.1: NaI / butan-2-one / 2 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; N-benzyl-trimethylammonium hydroxide; magnesium; triethylamine; sodium iodide; 5percent Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; butanone; 1.1: Metallation / 1.2: Formylation / 2.1: Catalytic hydrogenation / 3.1: Knoevenagel condensation / 4.1: ethanolysis / 5.1: Reduction / 6.1: mesylation / 7.1: Iodination;
DOI:10.1021/jm000173z