2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

Base Information

Chemical Name:2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester
CAS No.:903550-17-4
Molecular Formula:C₁₇H₂₄N₂O₃Si
Molecular Weight:332.475
Hs Code.:

2-[2-(2-trimethylsilanyl-ethoxymethyl)-2<i>H</i>-pyrazol-3-yl]-benzoic acid methyl ester

Synonyms:2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

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Chemical Property of 2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

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Technology Process of 2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

There total 3 articles about 2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 903550-12-9
5-(4,4,5,5-tetramethyl-[1,3 ,2]dioxaborolan-2-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole

: 610-94-6
2-bromobenzoic acid methyl ester

: 903550-17-4
2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; for 12h; Heating;
DOI:10.1016/j.tetlet.2006.04.125

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 903550-17-4
2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / sodium hydride / tetrahydrofuran / 20 °C

2.1: n-BuLi / tetrahydrofuran / -70 °C

2.2: triisopropylborate / tetrahydrofuran / -70 °C

2.3: 75 percent / AcOH / tetrahydrofuran / -70 °C

3.1: 73 percent / Pd(PPh₃)4; aq. sodium hydrogen carbonate / 1,2-dimethoxy-ethane / 12 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; 3.1: Suzuki cross-coupling;
DOI:10.1016/j.tetlet.2006.04.125

Reference yield:

: 133560-57-3
1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole

: 903550-17-4
2-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -70 °C

1.2: triisopropylborate / tetrahydrofuran / -70 °C

1.3: 75 percent / AcOH / tetrahydrofuran / -70 °C

2.1: 73 percent / Pd(PPh₃)4; aq. sodium hydrogen carbonate / 1,2-dimethoxy-ethane / 12 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; 2.1: Suzuki cross-coupling;
DOI:10.1016/j.tetlet.2006.04.125