1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole

Base Information

Chemical Name:1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole
CAS No.:133560-57-3
Molecular Formula:C9H18N2OSi
Molecular Weight:198.34
Hs Code.:
DSSTox Substance ID:DTXSID00576159
Nikkaji Number:J2.326.807H
Wikidata:Q82465711

Synonyms:133560-57-3;1-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-1H-PYRAZOLE;trimethyl-[2-(pyrazol-1-ylmethoxy)ethyl]silane;1H-Pyrazole, 1-[[2-(trimethylsilyl)ethoxy]methyl]-;1-[[2-(Trimethylsilyl)ethoxy]methyl]pyrazole;1-{[2-(TRIMETHYLSILYL)ETHOXY]METHYL}PYRAZOLE;MFCD12405511;1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazole;C9H18N2OSi;SCHEMBL11617;DTXSID00576159;UIPXBTCPQJIXTO-UHFFFAOYSA-N;AKOS025395184;AM806030;AS-39657;SY036246;CS-0036065

Suppliers and Price of 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:198.118839736
Heavy Atom Count:13
Complexity:147

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C[Si](C)(C)CCOCN1C=CC=N1

Technology Process of 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole

There total 2 articles about 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 288-13-1
NH-pyrazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 133560-57-3
1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.tetlet.2006.04.125

Reference yield:

: 844501-71-9,1086111-17-2
3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1146162-54-0
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole

: 133560-57-3
1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole

: 1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrazolyl-3-boronic acid

Guidance literature:: 3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield: 91.0%

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 133560-57-3
1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole

: 1174231-58-3
4-[2-(2-trimethylsilanyl-ethoxymethyl)-2H-pyrazol-3-yl]-benzoic acid ethyl ester

Guidance literature:: 1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole; With 2,2,6,6-tetramethyl-piperidyl-MgCl*LiCl; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

4-iodobenzoic acid ethyl ester; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; at 25 ℃; Inert atmosphere;
DOI:10.1021/ol901208d