ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

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Chemical Name:ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate
CAS No.:146625-03-8
Molecular Formula:C₂₇H₂₆F₃N₃O₃
Molecular Weight:497.517
Hs Code.:

Synonyms:ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

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Chemical Property of ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

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Technology Process of ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

There total 13 articles about ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 146625-02-7
ethyl 4-cyclopropyl-2-ethyl-1-<<2-(2-nitrophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-1H-imidazole-5-carboxylate

: 146625-03-8
ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 2h; under 760 Torr;
DOI:10.1021/jm00045a016

Reference yield:

: 612-25-9
2-Nitrobenzyl alcohol

: 146625-03-8
ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / dioxane / 1.5 h / 15 - 25 °C

2: 72 percent / NaI, K₂CO₃ / N,N-dimethyl-acetamide / 18 h

3: 30 percent / NaOMe / N,N-dimethyl-acetamide / 3 h / 0 - 25 °C

4: 100 percent / Ac₂O, conc. H₂SO₄ / 4.5 h / Heating

5: NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating; Irradiation

6: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, RT, 12 h

7: 78 percent / H₂, conc. aq. HCl / 10percent Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; hydrogen; sodium methylate; acetic anhydride; sodium hydride; potassium carbonate; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm00045a016

Reference yield:

: 70978-57-3
2,2,2-trifluoromethyl-1-(2-hydroxy-5-methylphenyl)ethan-1-one

: 146625-03-8
ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / NaI, K₂CO₃ / N,N-dimethyl-acetamide / 18 h

2: 30 percent / NaOMe / N,N-dimethyl-acetamide / 3 h / 0 - 25 °C

3: 100 percent / Ac₂O, conc. H₂SO₄ / 4.5 h / Heating

4: NBS, benzoyl peroxide / CCl₄ / 1.5 h / Heating; Irradiation

5: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, RT, 12 h

6: 78 percent / H₂, conc. aq. HCl / 10percent Pd/C / tetrahydrofuran / 2 h / 20 °C / 760 Torr

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; hydrogen; sodium methylate; acetic anhydride; sodium hydride; potassium carbonate; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm00045a016