70978-57-3

Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1-(2-hydroxy-5-methylphenyl)-ethanone is used as an intermediate in the synthesis of pharmaceuticals for its unique structure and reactivity, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 2,2,2-trifluoro-1-(2-hydroxy-5-methylphenyl)-ethanone serves as an intermediate in the synthesis of agrochemicals, playing a role in the creation of pesticides, herbicides, and other agricultural products.
Used in Research and Development:
2,2,2-Trifluoro-1-(2-hydroxy-5-methylphenyl)-ethanone is utilized in research and development processes across the pharmaceutical and agrochemical industries due to its distinctive fluorinated structure, which aids in the study of chemical and biological processes.

InChI:InChI=1/C9H7F3O2/c1-5-2-3-7(13)6(4-5)8(14)9(10,11)12/h2-4,13H,1H3

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 114212-23-6 2-(2-bromo-4-methylphenoxy)-tetrahydro-2H-pyran 
• 106-44-5 p-cresol 
• 407-25-0 trifluoroacetic anhydride 
• 104750-60-9 2-bromo-1-(methoxymethoxy)-4-methylbenzene 
• 6627-55-0 2-bromo-p-cresol 
• 1813-29-2 4-methylphenyl trifluoroacetate 
• 142-71-2 copper diacetate 

Downstream Products

• 70978-48-2 2-Hydroxy-5-methyl-3-nitrotrifluoroacetophenon 
• 70977-83-2 3-Amino-2-hydroxy-5-methyl-trifluoracetophenon 
• 70977-95-6 1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 2-hydroxy-5-methyl-3-trifluoroacetyl-anilide 
• 70977-64-9 1H-tetrazole-5-carboxylic acid 2-hydroxy-5-methyl-3-trifluoroacetyl-anilide 
• 146624-40-0 Ethyl 1-[[3-(trifluoromethyl)-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate 
• 146624-41-1 1-[[3-(Trifluoromethyl)-2-[2-[[(trifluoromethyl)sulphonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylic acid 
• 146625-02-7 ethyl 4-cyclopropyl-2-ethyl-1-<<2-(2-nitrophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-1H-imidazole-5-carboxylate 
• 146625-03-8 ethyl 1-<<2-(2-aminophenyl)-3-(2,2,2-trifluoromethyl)-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate 
• 146015-54-5 5-(bromomethyl)-2-(2-nitrophenyl)-3-(trifluoromethyl)-3-benzofuran 
• 146015-53-4 5-methyl-2-(2-nitrophenyl)-3-(trifluoromethyl)-3-benzofuran 
• 146015-51-2 2,2,2-trifluoro-1-<5-methyl-2-<(2-nitrophenyl)methoxy>phenyl>ethanone 

Relevant academic research and scientific papers

Enantioselective (3+2) cycloaddition: Via N-heterocyclic carbene-catalyzed addition of homoenolates to cyclic N -sulfonyl trifluoromethylated ketimines: Synthesis of fused N-heterocycle γ-lactams

An enantioselective (3+2) cycloaddition of enals and cyclic N-sulfonyl trifluoromethyl ketimines via N-heterocyclic carbene-catalyzed homoenolate addition is described. This reaction can efficiently construct fused N-heterocycle γ-lactams bearing two adjacent chiral centers with >20?:?1 dr and 94-99% ee, with one chiral center as a trifluoromethylated α-tetrasubstituted carbon stereocenter.

Isoxazoline derivative and applications in agriculture

The present invention provides an isoxazoline derivative and applications in agriculture, and particularly relates to a new isoxazoline derivative and a preparation method thereof, and a composition containing the compound, and applications in agriculture, particularly as the herbicide active ingredient in prevention and control of unwanted plants.

Highly Enantioselective Construction of Fluoroalkylated Quaternary Stereocenters via Organocatalytic Dehydrated Mannich Reaction of Unprotected Hemiaminals with Ketones

A general organocatalytic asymmetric dehydrated Mannich reaction of fluoroalkyl hemiaminals with ketones is reported. In this Mannich reaction, previously less explored aryl ketones showed great reactivity. By virtue of this efficient method, a wide range of biologically active β-amino ketones were directly obtained. More importantly, two different intermediates involved in the reaction were detected and identified by 19F NMR and HRMS analysis. Furthermore, the synthetic utility of the products was demonstrated by the synthesis of the biologically active fluoroalkyl β-amino alcohols.

Halogenation of fluorinated cyclic 1,3-dicarbonyl compounds: new aspects of synthetic application

In order to elaborate on an approach towards 2-(fluoroacyl)phenols being the superior alternative to the conventional Fries-rearrangement based methodology, the behaviour of cyclic fluorinated 1,3-dicarbonyls in reactions with halogenating agents was examined. The synthetic relevance of the polyhalogenated compounds obtained was demonstrated by the synthesis of several new heterocycles. An aromatization via a halogenation-dehydrohalogenation sequence proved to be a rewarding synthetic route to 2-(fluoroacyl)phenols and previously unknown 3-(fluoroacyl)thiochromones. The structure of one of the synthesized compounds was confirmed by X-ray diffraction analysis.