4-fluoro-5-hydroxy-2-nitrobenzoic acid

Base Information

• Chemical Name: 4-fluoro-5-hydroxy-2-nitrobenzoic acid
• CAS No.: 38569-85-6
• Molecular Formula: C₇H₄FNO₅
• Molecular Weight: 201.111
• Mol file: 38569-85-6.mol

Synonyms:4-fluoro-5-hydroxy-2-nitrobenzoic acid

Chemical Property of 4-fluoro-5-hydroxy-2-nitrobenzoic acid

Chemical Property:

• Boiling Point: 431.7±45.0 °C(Predicted)
• PKA: 2.02±0.25(Predicted)
• Density: 1.727±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-5-hydroxy-2-nitrobenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-5-hydroxy-2-nitrobenzoic acid

There total 2 articles about 4-fluoro-5-hydroxy-2-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,5-difluoro-2-nitrobenzoic acid (20372-63-8) → 4-fluoro-5-hydroxy-2-nitrobenzoic acid (38569-85-6)

Guidance literature:

With water; potassium hydroxide; at 50 - 90 ℃; for 0.833333h;

Reference yield:

→ 4-fluoro-5-hydroxy-2-nitrobenzoic acid (38569-85-6)

Guidance literature:

Aus 5-Amino-4-fluoro-2-nitrobenzoesaeure III mit KOH;

Reference yield: 85.0%

4-fluoro-5-hydroxy-2-nitrobenzoic acid (38569-85-6) → methyl 4-fluoro-5-hydroxy-2-nitrobenzoate (1426958-40-8)

Guidance literature:

With methanol; sulfuric acid; at 10 - 75 ℃; Inert atmosphere;

upstream raw materials:

4,5-difluoro-2-nitrobenzoic acid

Downstream raw materials:

methyl 4-fluoro-5-hydroxy-2-nitrobenzoate

Refernces