20372-63-8

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Difluoro-2-nitrobenzoic acid is used as an intermediate in the synthesis of pharmaceutical compounds for treating various diseases. Its unique structure allows it to be a key component in the development of new drugs with improved efficacy and selectivity.
Used in Chemical Research:
In the field of chemical research, 4,5-Difluoro-2-nitrobenzoic acid serves as a valuable compound for studying the effects of fluorination and nitration on the chemical and physical properties of benzoic acid derivatives. This helps in understanding the reactivity and stability of these compounds, which is crucial for their application in various chemical processes.
Used in Material Science:
4,5-Difluoro-2-nitrobenzoic acid is used in the development of new materials with specific properties, such as high thermal stability, chemical resistance, and unique optical characteristics. These materials can be employed in various applications, including coatings, adhesives, and polymers.
Used in Agrochemical Industry:
In the agrochemical industry, 4,5-Difluoro-2-nitrobenzoic acid is utilized as a building block for the synthesis of active ingredients in pesticides and herbicides. Its unique structure contributes to the development of more effective and environmentally friendly agrochemicals.
Overall, 4,5-Difluoro-2-nitrobenzoic acid is a versatile compound with a wide range of applications across various industries, including pharmaceuticals, chemical research, material science, and agrochemicals. Its unique properties and reactivity make it an essential component in the development of new and improved products.

InChI:InChI=1/C7H3F2NO4/c8-4-1-3(7(11)12)6(10(13)14)2-5(4)9/h1-2H,(H,11,12)

Upstream product

• 455-86-7 3,4-Difluorobenzoic acid 
• 127371-50-0 1,2-difluoro-4-methyl-5-nitrobenzene 

Downstream Products

• 329939-78-8 4,5-difluoro-2-nitro-phenylacetamide 
• 1015433-96-1 methyl 4,5-difluoro-2-nitrobenzoate 
• 127451-97-2 ethyl 3,4-difluoro-2-nitrobenzoylacetate 
• 346687-15-8 diethyl 2-(4,5-difluoro-2-nitrobenzoyl)malonate 
• 611199-31-6 ethyl 2-(4,5-difluoro-2-nitrobenzoyl)-3-oxobutanoate 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 887244-09-9 methyl (2S)-cyclohexyl-{[(4,5-difluoro-2-nitrophenyl)carbonyl]amino}ethanoate 
• 914095-13-9 (4,5-difluoro-2-nitrophenyl)methanol 
• 1214387-06-0 4,5-difluoro-2-nitrobenzoic acid ethyl ester 
• 1113049-59-4 5-(benzyloxy)-4-fluoro-2-nitrobenzoic acid 
• 149169-49-3 4,5-difluoro-2-nitrobenzaldehyde 
• 1413931-06-2 C₂₄H₁₆Cl₂F₂N₂O₄ 

Relevant academic research and scientific papers

PLATELET ADP RECEPTOR INHIBITORS

Compounds are provided which are useful as platelet ADP receptor inhibitors, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

Synthesis of 4-Hydroxyquinolin-2(1H)-one analogues and 2-substituted quinolone derivatives

A versatile synthetic method for preparing 4-hydroxyquinolone and 2-substituted quinolone compounds from simple benzoic acid derivatives was demonstrated. The synthetic strategies involve the use of well known ethyl acetoacetate synthesis, malonic ester s

Synthesis and antibacterial activity of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

A series of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids was prepared and evaluated for antibacterial activity. The 6-fluoro-2-methyl-1-prenyl-1,4-dihydro-7-(3,5-dimethylpiperazinyl)-4-oxo-3-quinolinecarboxylic acid (14f) exhibited

Process for the preparation of 4,5-difluoroanthranilic acid from 4,5-difluorophthalic anhydride or 4,5-difluorophthalic acid

4,5-Difluoroanthranilic acid may be prepared by decarboxylating 4,5-difluorophthalic anhydride or 4,5-difluorophthalic acid by heating in dimethyl acetamide, N-methyl-2-pyrrolidone or quinoline, optionally by reaction with copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst, whereby 3,4-difluorobenzoic acid is formed; nitrating said 3,4-difluorobenzoic acid in a mixture of nitric and sulfuric acids to form 2-nitro-4,5-difluorobenzoic acid, and reducing said 2-nitro-4,5-difluorobenzoic acid to form 4,5-difluoroanthranilic acid.

Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-difluorophthalic anhydride of 4,5-difluorophthalic acid

2-Chloro-4,5-difluorobenzoic acid may be prepared by decarboxylating 4,5-difluorophthalic anhydride or 4,5-difluorophthalic acid by heating in N-methyl-2-pyrrolidone or dimethyl acetamide optionally using copper, copper oxide, copper salts, or halides or salts of Zn, Cd, Ag and Ni as a catalyst to form 3,4-difluorobenzoic acid, reacting said 3,4-difluorobenzoic acid with a mixture of nitric and sulfuric acids to form 2-nitro-4,5-difluorobenzoic acid, reacting said 2-nitro-4,5-difluorobenzoic acid with elemental chlorine at a temperature of between 185° and 195° C. to form 2-chloro-4,5-difluorobenzoic acid.

Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters

Compounds of the formula: wherein Y is OR1, fluoro, chloro, methyl, R1, and R3 are independently selected from hydrogen and C1-C4 alkyl, R2 is C1-C4 alkyl and X is fluoro, chloro or bromo, with the proviso that when Y is OH, X cannot be bromo and with the proviso that X can be fluoro only if R2 is methyl.