20372-63-8

Basic information

• Product Name: 4,5-Difluoro-2-nitrobenzoic acid
• Synonyms: 2-NITRO-4,5-DIFLUOROBENZOIC ACID;4,5-DIFLUORO-2-NITROBENZOIC ACID;4,5-difluoro-2-nitrobenzenecarboxylic acid;4,5-two fluoro -2-Nitrobenzoic Acid
• CAS NO: 20372-63-8
• Molecular Formula: C₇H₃F₂NO₄
• Molecular Weight: 203.1
• EINECS: 1533716-785-6
• Product Categories: Acids and Derivatives;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;API intermediates;C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 20372-63-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 165-167 °C(lit.)
• Boiling Point: 349.7 °C at 760 mmHg
• Flash Point: 165.3 °C
• Appearance: powder
• Density: 1.661 g/cm³
• Vapor Pressure: 1.73E-05mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.85±0.25(Predicted)
• CAS DataBase Reference: 4,5-Difluoro-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Difluoro-2-nitrobenzoic acid(20372-63-8)
• EPA Substance Registry System: 4,5-Difluoro-2-nitrobenzoic acid(20372-63-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 20372-63-8(Hazardous Substances Data)

Usage

Chemical Properties

Solid

General Description

4,5-Difluoro-2-nitrobenzoic acid can be obtained from the nitration of 4,5-difluorobenzoic acid or 3,4-difluorobenzoic acid.

InChI:InChI=1/C7H3F2NO4/c8-4-1-3(7(11)12)6(10(13)14)2-5(4)9/h1-2H,(H,11,12)

Upstream product

• 127371-50-0 1,2-difluoro-4-methyl-5-nitrobenzene 
• 455-86-7 3,4-Difluorobenzoic acid 

Downstream Products

• 914095-13-9 (4,5-difluoro-2-nitrophenyl)methanol 
• 1015433-96-1 methyl 4,5-difluoro-2-nitrobenzoate 
• 1214387-06-0 4,5-difluoro-2-nitrobenzoic acid ethyl ester 
• 149169-49-3 4,5-difluoro-2-nitrobenzaldehyde 
• 1426958-40-8 methyl 4-fluoro-5-hydroxy-2-nitrobenzoate 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 127451-97-2 ethyl 3,4-difluoro-2-nitrobenzoylacetate 
• 383875-96-5 6,7-difluoro-2-phenyl-1-prenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 

Relevant articles and documents

PLATELET ADP RECEPTOR INHIBITORS

Compounds are provided which are useful as platelet ADP receptor inhibitors, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

Synthesis and antibacterial activity of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

A series of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids was prepared and evaluated for antibacterial activity. The 6-fluoro-2-methyl-1-prenyl-1,4-dihydro-7-(3,5-dimethylpiperazinyl)-4-oxo-3-quinolinecarboxylic acid (14f) exhibited

Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-difluorophthalic anhydride of 4,5-difluorophthalic acid

2-Chloro-4,5-difluorobenzoic acid may be prepared by decarboxylating 4,5-difluorophthalic anhydride or 4,5-difluorophthalic acid by heating in N-methyl-2-pyrrolidone or dimethyl acetamide optionally using copper, copper oxide, copper salts, or halides or salts of Zn, Cd, Ag and Ni as a catalyst to form 3,4-difluorobenzoic acid, reacting said 3,4-difluorobenzoic acid with a mixture of nitric and sulfuric acids to form 2-nitro-4,5-difluorobenzoic acid, reacting said 2-nitro-4,5-difluorobenzoic acid with elemental chlorine at a temperature of between 185° and 195° C. to form 2-chloro-4,5-difluorobenzoic acid.