2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester
CAS No.:207226-52-6
Molecular Formula:C₂₁H₃₀O₄
Molecular Weight:346.467
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

Suppliers and Price of 2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 79026-61-2
(R)-3-benzyloxy-2-methylpropanal

: 2,2-Dimethyl-propionic acid 2-tributylstannanyl-penta-2,3-dienyl ester

: 207226-52-6
2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

Guidance literature:: With tin(IV) chloride; In dichloromethane; 1.) 0 deg C, 40 min, 2.) -78 deg C, 4.5 h;
DOI:10.1021/jo980137w

Reference yield: 92.0%

: 207226-52-6
2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

: 207226-62-8
(E)-(4S,5S,6R)-7-Benzyloxy-4,6-dimethyl-hept-2-ene-1,5-diol

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 0 - 20 ℃; for 48h;
DOI:10.1021/jo980137w

Reference yield:

: 207226-52-6
2,2-Dimethyl-propionic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

: 81470-85-1
(R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / Red-Al / tetrahydrofuran / 48 h / 0 - 20 °C

2: (+)-DIPT, Ti(O-i-Pr)4, t-BuOOH / CH₂Cl₂ / 18 h / -25 °C

3: CuCN / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 30 min, 2.) 36 h

4: imidazole / dimethylformamide / 18 h / 0 - 20 °C

5: CSA / 3 h / Ambient temperature

6: H₂ / 5percent Pd/C / ethyl acetate / 17 h

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; camphor-10-sulfonic acid; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo980137w